HCSGD entry for HBZ
1. General information
| Official gene symbol | HBZ |
|---|---|
| Entrez ID | 3050 |
| Gene full name | hemoglobin, zeta |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0005344 | Oxygen transporter activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005833 | Hemoglobin complex | IEA | cellular_component |
| GO:0019825 | Oxygen binding | IEA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0043249 | Erythrocyte maturation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6537625926 | 0.8364825766 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0093721399 |
| GSE13712_SHEAR | Down | -0.0087209416 |
| GSE13712_STATIC | Down | -0.0573512718 |
| GSE19018 | Down | -0.0781086680 |
| GSE19899_A1 | Up | 0.0607922410 |
| GSE19899_A2 | Down | -0.1514785436 |
| PubMed_21979375_A1 | Up | 0.0628687388 |
| PubMed_21979375_A2 | Down | -0.2327800542 |
| GSE35957 | Up | 0.1673794483 |
| GSE36640 | Up | 0.1062549512 |
| GSE54402 | Down | -0.0013805031 |
| GSE9593 | Up | 0.0681390351 |
| GSE43922 | Down | -0.0318182694 |
| GSE24585 | Up | 0.2736631735 |
| GSE37065 | Up | 0.0132085247 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.2332470980 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21552325 | NF-kappaB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ |
| 21552325 | Finally, we show that down-regulation of NF-kappaB by the HTLV-1 anti-sense protein, HBZ, delay or prevent the onset of Tax-induced senescence |
| 21552325 | We propose that the balance between Tax and HBZ expression determines the outcome of HTLV-1 infection |
| 21552325 | HBZ, however, modulates Tax-mediated viral replication and NF-kappaB activation, thus allowing HTLV-1-infected cells to proliferate, persist, and evolve |
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