HCSGD entry for HBA2
1. General information
| Official gene symbol | HBA2 |
|---|---|
| Entrez ID | 3040 |
| Gene full name | hemoglobin, alpha 2 |
| Other gene symbols | HBH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005344 | Oxygen transporter activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005833 | Hemoglobin complex | IEA | cellular_component |
| GO:0019825 | Oxygen binding | IEA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9705616504 | 0.0412204741 | 0.9999902473 | 0.3824335918 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.7534906463 |
| GSE28863_A2 | Down | -0.7836818530 |
| GSE28863_A3 | Up | 0.6443192058 |
| GSE28863_A4 | Up | 0.0695956825 |
| GSE48662 | Down | -0.3524116165 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Mefloquine | DB00358 | APRD00300 |
| Iron Dextran | DB00893 | APRD01053 |
| 4-Carboxycinnamic Acid | DB02126 | EXPT00919 |
| 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine | DB07427 | - |
| 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine | DB07428 | - |
| SEBACIC ACID | DB07645 | - |
| 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID | DB08077 | - |
| 2,6-dicarboxynaphthalene | DB08262 | - |
| 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID | DB08486 | - |
| 1,3,5-BENZENETRICARBOXYLIC ACID | DB08632 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9141625 | We found that microcell fusion induced the nonerythroid recipient cells to express alpha-globin mRNA in a dose-dependent manner |
| 7250116 | In alpha-thalassaemic subjects originally from this region globin mRNA translation and alpha-globin gene arrangement have been investigated |
| 7250116 | The data obtained indicate that alpha-globin synthesis and reticulocyte alpha-globin mRNA are reduced by one fourth; in addition, since the defect in alpha-globin synthesis does not change with cell ageing, a possible instability of alpha-globin mRNA is excluded |
| 7250116 | Restriction enzyme analysis of the DNA shows a normal alpha-globin gene organization |
| 7250116 | This form of alpha-thalassaemia is therefore of the non-deletion type; its molecular lesion is either at the level of alpha-globin mRNA transcription or processing |
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