HCSGD entry for HADH
1. General information
| Official gene symbol | HADH |
|---|---|
| Entrez ID | 3033 |
| Gene full name | hydroxyacyl-CoA dehydrogenase |
| Other gene symbols | HAD HADH1 HADHSC HCDH HHF4 MSCHAD SCHAD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006631 | Fatty acid metabolic process | IEA | biological_process |
| GO:0006635 | Fatty acid beta-oxidation | IEA TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070403 | NAD+ binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9975689336 | 0.0005439193 | 0.9999902473 | 0.0435151976 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2210073956 |
| GSE13712_SHEAR | Down | -0.9675903331 |
| GSE13712_STATIC | Down | -0.7970164401 |
| GSE19018 | Up | 0.2234404996 |
| GSE19899_A1 | Down | -1.3560860182 |
| GSE19899_A2 | Down | -2.5762804986 |
| PubMed_21979375_A1 | Down | -2.1071693161 |
| PubMed_21979375_A2 | Down | -2.7481106646 |
| GSE35957 | Up | 0.0086379239 |
| GSE36640 | Down | -0.9559848586 |
| GSE54402 | Down | -1.0426714282 |
| GSE9593 | Down | -0.4969783216 |
| GSE43922 | Down | -1.3193258376 |
| GSE24585 | Down | -0.3144233778 |
| GSE37065 | Down | -0.1326333367 |
| GSE28863_A1 | Up | 0.0520064227 |
| GSE28863_A2 | Up | 0.0998177939 |
| GSE28863_A3 | Down | -0.3352139079 |
| GSE28863_A4 | Down | -0.0956161076 |
| GSE48662 | Down | -0.3105732390 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Acetoacetyl-Coenzyme A | DB03059 | EXPT00820 |
| 3-Hydroxybutyryl-Coenzyme A | DB03612 | EXPT00172 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT004893 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT004893 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023932 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023932 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024384 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026706 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029744 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037367 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043605 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
