HCSGD entry for HADHA
1. General information
| Official gene symbol | HADHA |
|---|---|
| Entrez ID | 3030 |
| Gene full name | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
| Other gene symbols | ECHA GBP HADH LCEH LCHAD MTPA TP-ALPHA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000062 | Fatty-acyl-CoA binding | IEA | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | IEA TAS | molecular_function |
| GO:0003985 | Acetyl-CoA C-acetyltransferase activity | TAS | molecular_function |
| GO:0004300 | Enoyl-CoA hydratase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0006631 | Fatty acid metabolic process | IEA | biological_process |
| GO:0006635 | Fatty acid beta-oxidation | IEA TAS | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0016507 | Mitochondrial fatty acid beta-oxidation multienzyme complex | IEA | cellular_component |
| GO:0016508 | Long-chain-enoyl-CoA hydratase activity | IEA | molecular_function |
| GO:0016509 | Long-chain-3-hydroxyacyl-CoA dehydrogenase activity | IEA | molecular_function |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0035965 | Cardiolipin acyl-chain remodeling | TAS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0050662 | Coenzyme binding | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2940753961 | 0.8601937730 | 0.9941055605 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3316992857 |
| GSE13712_SHEAR | Down | -0.1291228696 |
| GSE13712_STATIC | Down | -0.0314021401 |
| GSE19018 | Up | 0.0726668042 |
| GSE19899_A1 | Up | 0.1397789052 |
| GSE19899_A2 | Up | 0.1402464406 |
| PubMed_21979375_A1 | Up | 0.2624437462 |
| PubMed_21979375_A2 | Up | 0.1312145736 |
| GSE35957 | Down | -0.2891167286 |
| GSE36640 | Up | 0.1572676970 |
| GSE54402 | Up | 0.2238296154 |
| GSE9593 | Up | 0.4769879209 |
| GSE43922 | Down | -0.0306822586 |
| GSE24585 | Down | -0.0237303999 |
| GSE37065 | Down | -0.0507902270 |
| GSE28863_A1 | Up | 0.1282916743 |
| GSE28863_A2 | Up | 0.0674015515 |
| GSE28863_A3 | Down | -0.1762607907 |
| GSE28863_A4 | Down | -0.1667469176 |
| GSE48662 | Up | 0.1230574487 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022799 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037157 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039455 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040109 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042269 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049028 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052018 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
