HCSGD entry for GZMB
1. General information
| Official gene symbol | GZMB |
|---|---|
| Entrez ID | 3002 |
| Gene full name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Other gene symbols | CCPI CGL-1 CGL1 CSP-B CSPB CTLA1 CTSGL1 HLP SECT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001772 | Immunological synapse | TAS | cellular_component |
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
| GO:0019835 | Cytolysis | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:1900740 | Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4698358117 | 0.8814285020 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0677032488 |
| GSE13712_SHEAR | Up | 0.0243339101 |
| GSE13712_STATIC | Up | 0.0299428253 |
| GSE19018 | Up | 0.0918416612 |
| GSE19899_A1 | Down | -0.0055609203 |
| GSE19899_A2 | Up | 0.1703827984 |
| PubMed_21979375_A1 | Up | 0.2152860131 |
| PubMed_21979375_A2 | Up | 0.1804857366 |
| GSE35957 | Down | -0.0911804840 |
| GSE36640 | Down | -0.2483338931 |
| GSE54402 | Up | 0.1429683588 |
| GSE9593 | Up | 0.1048368420 |
| GSE43922 | Up | 0.0242178010 |
| GSE24585 | Down | -0.3159881807 |
| GSE37065 | Down | -0.0168747687 |
| GSE28863_A1 | Down | -0.0283961398 |
| GSE28863_A2 | Up | 0.1336909380 |
| GSE28863_A3 | Up | 0.1423780429 |
| GSE28863_A4 | Up | 0.1134753895 |
| GSE48662 | Up | 0.2593940984 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19220836 | Natural killer (NK)-like T cell receptors (CD94, 158) and intracellular perforin, granzyme B were increased in CD4(+)CD28(null) cells |
| 19220836 | These CD4(+)CD28(null) T cells show increased expression of NK-like T cell receptors (CD94, 158) and intracellular perforin and granzyme B |
| 19133932 | The measurements of the alloimmune response-infiltrate, cytology, expression of perforin, granzyme B, IFN-gamma and MHC-were not increased in old allografts |
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