HCSGD entry for CNOT7

1. General information

Official gene symbolCNOT7
Entrez ID29883
Gene full nameCCR4-NOT transcription complex, subunit 7
Other gene symbolsCAF1 hCAF-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityIDAmolecular_function
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningIEA TASbiological_process
GO:0000290Deadenylation-dependent decapping of nuclear-transcribed mRNAIEAbiological_process
GO:0000932Cytoplasmic mRNA processing bodyIEA ISScellular_component
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0004532Exoribonuclease activityIDAmolecular_function
GO:0004535Poly(A)-specific ribonuclease activityIDA IEAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006417Regulation of translationIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0030014CCR4-NOT complexIDA IEA NAScellular_component
GO:0031047Gene silencing by RNAIEA ISSbiological_process
GO:0033962Cytoplasmic mRNA processing body assemblyIEAbiological_process
GO:0035195Gene silencing by miRNATASbiological_process
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060213Positive regulation of nuclear-transcribed mRNA poly(A) tail shorteningIMPbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDAbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDAbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticIDAbiological_process
GO:1900153Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98784146120.04232448240.99999024730.3871147672

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0805792025
GSE13712_SHEARUp0.0009030306
GSE13712_STATICDown-0.1674740873
GSE19018Up0.0853480718
GSE19899_A1Down-0.2747673678
GSE19899_A2Down-0.4837726232
PubMed_21979375_A1Down-0.4776643935
PubMed_21979375_A2Down-0.5035800991
GSE35957Up0.0052517033
GSE36640Down-0.6165888258
GSE54402Down-0.0538446616
GSE9593Down-0.2083680300
GSE43922Down-0.0460106998
GSE24585Down-0.0902492705
GSE37065Down-0.0523664136
GSE28863_A1Down-0.1081175927
GSE28863_A2Down-0.1308278139
GSE28863_A3Down-0.6776644387
GSE28863_A4Up0.1107754841
GSE48662Down-0.1176401508

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031760ProteomicsFunctional MTI (Weak)18668040
hsa-miR-106b-5pMIMAT0000680MIRT044358CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.