HCSGD entry for ANAPC2

1. General information

Official gene symbolANAPC2
Entrez ID29882
Gene full nameanaphase promoting complex subunit 2
Other gene symbolsAPC2 RP11-350O14.5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004842Ubiquitin-protein ligase activityTASmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0008054Cyclin catabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0031915Positive regulation of synaptic plasticityISSbiological_process
GO:0045773Positive regulation of axon extensionIEAbiological_process
GO:0050775Positive regulation of dendrite morphogenesisIEAbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
GO:0090129Positive regulation of synapse maturationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18294931420.72553586490.83658945451.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0050217359
GSE13712_SHEARUp0.2705596869
GSE13712_STATICUp0.0251919334
GSE19018Up0.0701586236
GSE19899_A1Down-0.0242512976
GSE19899_A2Up0.5334070250
PubMed_21979375_A1Down-0.0616857198
PubMed_21979375_A2Up2.2679639773
GSE35957Up0.1430983049
GSE36640Up0.0662926056
GSE54402Down-0.1335864957
GSE9593Down-0.4075803737
GSE43922Up0.0488591355
GSE24585Down-0.0919583209
GSE37065Up0.0120103061
GSE28863_A1Down-0.1586981705
GSE28863_A2Down-0.0312464563
GSE28863_A3Up0.0871856408
GSE28863_A4Up0.1048274231
GSE48662Up0.2280009228

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.