HCSGD entry for GUCY1B3
1. General information
| Official gene symbol | GUCY1B3 |
|---|---|
| Entrez ID | 2983 |
| Gene full name | guanylate cyclase 1, soluble, beta 3 |
| Other gene symbols | GC-S-beta-1 GC-SB3 GUC1B3 GUCB3 GUCSB3 GUCY1B1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0004383 | Guanylate cyclase activity | IEA | molecular_function |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0007263 | Nitric oxide mediated signal transduction | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0008074 | Guanylate cyclase complex, soluble | IEA | cellular_component |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043167 | Ion binding | IEA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0051879 | Hsp90 protein binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9833761901 | 0.0014273736 | 0.9999902473 | 0.0729512621 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0151522866 |
| GSE13712_SHEAR | Down | -2.1127881138 |
| GSE13712_STATIC | Down | -1.1799625528 |
| GSE19018 | Down | -0.4600633882 |
| GSE19899_A1 | Down | -0.3514397848 |
| GSE19899_A2 | Down | -2.3625567924 |
| PubMed_21979375_A1 | Down | -0.8541382384 |
| PubMed_21979375_A2 | Down | -1.2496661168 |
| GSE35957 | Down | -0.8118702131 |
| GSE36640 | Down | -1.3346228646 |
| GSE54402 | Down | -0.5665832043 |
| GSE9593 | Down | -0.2422294165 |
| GSE43922 | Down | -0.8191835954 |
| GSE24585 | Up | 0.8223029190 |
| GSE37065 | Down | -0.1785295532 |
| GSE28863_A1 | Up | 0.2091937203 |
| GSE28863_A2 | Down | -0.4116530054 |
| GSE28863_A3 | Up | 0.0541809134 |
| GSE28863_A4 | Down | -0.0239272404 |
| GSE48662 | Down | -0.1623825734 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT045241 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
