HCSGD entry for GTF3C1
1. General information
| Official gene symbol | GTF3C1 |
|---|---|
| Entrez ID | 2975 |
| Gene full name | general transcription factor IIIC, polypeptide 1, alpha 220kDa |
| Other gene symbols | TFIIIC TFIIIC220 TFIIICalpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000127 | Transcription factor TFIIIC complex | IDA | cellular_component |
| GO:0003677 | DNA binding | IC | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IC | biological_process |
| GO:0006383 | Transcription from RNA polymerase III promoter | IC TAS | biological_process |
| GO:0009303 | RRNA transcription | TAS | biological_process |
| GO:0009304 | TRNA transcription | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter | IC | biological_process |
| GO:0042797 | TRNA transcription from RNA polymerase III promoter | IC | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0184490749 | 0.9822310930 | 0.3321464432 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3476985112 |
| GSE13712_SHEAR | Down | -0.0894217412 |
| GSE13712_STATIC | Down | -0.0062821363 |
| GSE19018 | Up | 0.0855850236 |
| GSE19899_A1 | Up | 0.0637860103 |
| GSE19899_A2 | Up | 0.5169970702 |
| PubMed_21979375_A1 | Up | 0.8166277172 |
| PubMed_21979375_A2 | Up | 2.0557721152 |
| GSE35957 | Down | -0.1433894336 |
| GSE36640 | Up | 0.0910857655 |
| GSE54402 | Up | 0.1250158609 |
| GSE9593 | Down | -0.0111194994 |
| GSE43922 | Up | 0.2894227192 |
| GSE24585 | Down | -0.1040715110 |
| GSE37065 | Down | -0.0964991246 |
| GSE28863_A1 | Up | 0.9505338960 |
| GSE28863_A2 | Up | 1.1181670859 |
| GSE28863_A3 | Up | 0.0698631842 |
| GSE28863_A4 | Up | 0.0663394365 |
| GSE48662 | Up | 0.1776194988 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025502 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031871 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036135 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-941 | MIMAT0004984 | MIRT036584 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-935 | MIMAT0004978 | MIRT036692 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-760 | MIMAT0004957 | MIRT036747 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040008 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-598-3p | MIMAT0003266 | MIRT040489 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042291 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043154 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049374 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051696 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051862 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052302 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052608 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052747 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
