HCSGD entry for GSTT1
1. General information
| Official gene symbol | GSTT1 |
|---|---|
| Entrez ID | 2952 |
| Gene full name | glutathione S-transferase theta 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004364 | Glutathione transferase activity | IDA IEA | molecular_function |
| GO:0004602 | Glutathione peroxidase activity | IDA IEA | molecular_function |
| GO:0005829 | Cytosol | IDA IEA TAS | cellular_component |
| GO:0006749 | Glutathione metabolic process | IDA IEA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:1901687 | Glutathione derivative biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4591811633 | 0.2763013715 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1317018736 |
| GSE13712_SHEAR | Down | -0.1424111712 |
| GSE13712_STATIC | Up | 0.1679348416 |
| GSE19018 | Up | 0.0222719975 |
| GSE19899_A1 | Up | 0.0844154151 |
| GSE19899_A2 | Up | 0.0784665563 |
| PubMed_21979375_A1 | Up | 0.0013755663 |
| PubMed_21979375_A2 | Up | 0.0548209053 |
| GSE35957 | Up | 0.5679483252 |
| GSE36640 | Up | 0.0504409343 |
| GSE54402 | Down | -0.0072083241 |
| GSE9593 | Up | 0.1511275495 |
| GSE43922 | Up | 0.0348162981 |
| GSE24585 | Down | -0.0541649402 |
| GSE37065 | Down | -0.4021326585 |
| GSE28863_A1 | Down | -0.1517864053 |
| GSE28863_A2 | Up | 0.0906687247 |
| GSE28863_A3 | Down | -0.7912268431 |
| GSE28863_A4 | Up | 0.0976904640 |
| GSE48662 | Up | 0.2188515647 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15195682 | We found a statistically significant difference in the frequency of 1the GSTT1 deletion and the p53 genotypes: the absence of any p53 polymorphisms and of GSTT1 deletion, and the simultaneous presence of the three p53 polymorphisms and of GSTT1 deletion, were much more frequent in young subjects than in centenarians (41 |
| 15195682 | One hypothesis to explain this difference is that subjects with both GSTT1 deletion and p53 polymorphisms may accumulate carcinogens and may have reduced DNA repair ability, and thus are more at risk for cancer |
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