HCSGD entry for GSTM2

1. General information

Official gene symbolGSTM2
Entrez ID2946
Gene full nameglutathione S-transferase mu 2 (muscle)
Other gene symbolsGST4 GSTM GSTM2-2 GTHMUS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004364Glutathione transferase activityIDA IEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006749Glutathione metabolic processIDAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIDAbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionICbiological_process
GO:0014809Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionICbiological_process
GO:0016529Sarcoplasmic reticulumIDAcellular_component
GO:0018916Nitrobenzene metabolic processIDAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0042178Xenobiotic catabolic processIDAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043295Glutathione bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0055119Relaxation of cardiac muscleTASbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDAbiological_process
GO:0060316Positive regulation of ryanodine-sensitive calcium-release channel activityIDAbiological_process
GO:0070458Cellular detoxification of nitrogen compoundIDAbiological_process
GO:0071313Cellular response to caffeineIDAbiological_process
GO:1901687Glutathione derivative biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65328965460.01476257740.99999024730.2394811460

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2476958034
GSE13712_SHEARDown-1.2352186223
GSE13712_STATICDown-0.7492044123
GSE19018Down-0.2027384915
GSE19899_A1Down-1.1507390065
GSE19899_A2Down-0.3782656055
PubMed_21979375_A1Down-2.4848305957
PubMed_21979375_A2Down-0.9137255562
GSE35957Up0.6350539529
GSE36640Up1.1500675415
GSE54402Down-1.3450186732
GSE9593Up0.4987264796
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.6514805865

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlutathioneDB00143 NUTR00029 | EXPT01650
Glutathione S-(2,4 Dinitrobenzene)DB02458 EXPT01572 | DB04412
Oxidized Glutathione DisulfideDB03310 EXPT01575
S-METHYL-GLUTATHIONEDB04701 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT025057MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.