HCSGD entry for GSN

1. General information

Official gene symbolGSN
Entrez ID2934
Gene full namegelsolin
Other gene symbolsADF AGEL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIEAcellular_component
GO:0003779Actin bindingIEAmolecular_function
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA ISS NAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005829CytosolIDA ISS TAScellular_component
GO:0006915Apoptotic processIEA TASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008154Actin polymerization or depolymerizationIEAbiological_process
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0015629Actin cytoskeletonIEAcellular_component
GO:0016192Vesicle-mediated transportIEAbiological_process
GO:0030027LamellipodiumIEAcellular_component
GO:0030041Actin filament polymerizationIDA ISSbiological_process
GO:0030155Regulation of cell adhesionIEAbiological_process
GO:0042246Tissue regenerationIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051014Actin filament severingIDA ISSbiological_process
GO:0051016Barbed-end actin filament cappingTASbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0060271Cilium morphogenesisIMPbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0071276Cellular response to cadmium ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27798911520.18009743930.97515684970.8216926157

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0937040754
GSE13712_SHEARUp0.0219126469
GSE13712_STATICDown-0.3126460938
GSE19018Up0.2147045628
GSE19899_A1Down-0.1174045914
GSE19899_A2Down-0.1422001158
PubMed_21979375_A1Down-0.8721787982
PubMed_21979375_A2Down-0.5798770310
GSE35957Up0.2435939726
GSE36640Up0.7068614069
GSE54402Down-0.8206317665
GSE9593Up0.3374667107
GSE43922Down-0.5588057325
GSE24585Up0.7546626909
GSE37065Down-0.1194220501
GSE28863_A1Up0.2883339634
GSE28863_A2Up0.1131721697
GSE28863_A3Down-0.0635768880
GSE28863_A4Up0.1233513928
GSE48662Up0.3275388160

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Latrunculin ADB02621 EXPT02004

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002639MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002639MicroarrayFunctional MTI (Weak)18668037
hsa-miR-335-5pMIMAT0000765MIRT018068MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25989853Finally, baseline and ATP-induced [Ca(2+)]int levels were significantly increased in microglia lacking gelsolin, a key actin-severing protein
15033777Gelsolin for senescence-associated resistance to apoptosis
15033777Gelsolin, a Ca(2+)-dependent actin regulatory protein, is believed to regulate the intracellular movements which are necessary for cell growth, proliferation, and differentiation
15033777Recently, gelsolin was suggested to play a role in apoptotic resistance, which led us to examine its involvement in the apoptotic resistance of senescent cells
15033777We found that the protein and mRNA levels of gelsolin were increased in senescent human diploid fibroblasts (HDFs)
15033777To examine the anti-apoptotic function of gelsolin in senescent HDFs, we tried to downregulate the expression of gelsolin by using antisense oligonucleotide in old HDFs
15033777Downregulation of gelsolin in senescent HDFs resulted in increased sensitivity to menadione-induced apoptotic cell death
15033777This suggests that gelsolin plays a role in the apoptotic resistance observed in senescent HDFs
14652020Aging-associated increase of gelsolin for apoptosis resistance
14652020Gelsolin, a Ca(2+)-dependent actin regulatory protein, was recently suggested to participate in apoptosis regulation
14652020In this study, we found that the level of gelsolin is elevated in senescent human diploid fibroblasts (HDFs) and also in the tissues of old rats, i
14652020The ubiquitous increase of gelsolin in the aged organs and cells led us to assume that it might be related with one of the cardinal senescent phenotypes, aging-associated apoptosis resistency
14652020Thus, we tested the sensitivity of senescent cells to apoptosis by menadione, an apoptosis-inducing agent, before and after the down-regulation of gelsolin
14652020The down-regulation of gelsolin in senescent HDFs, independently of Bcl-2 family expression, resulted in an increased sensitivity to menadione-induced apoptotic cell death
14652020The observed ubiquitous increase of gelsolin in the senescent states of cells and tissues, and the increased sensitivity to apoptosis-induction by gelsolin down-regulation, suggests that gelsolin would be partly responsible for age-related apoptosis resistance
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