HCSGD entry for PDIA3

1. General information

Official gene symbolPDIA3
Entrez ID2923
Gene full nameprotein disulfide isomerase family A, member 3
Other gene symbolsER60 ERp57 ERp60 ERp61 GRP57 GRP58 HsT17083 P58 PI-PLC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0003756Protein disulfide isomerase activityIEAmolecular_function
GO:0004197Cysteine-type endopeptidase activityTASmolecular_function
GO:0004629Phospholipase C activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIDA TAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0006457Protein foldingTASbiological_process
GO:0006606Protein import into nucleusTASbiological_process
GO:0006621Protein retention in ER lumenTASbiological_process
GO:0006662Glycerol ether metabolic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0015035Protein disulfide oxidoreductase activityIEAmolecular_function
GO:0016853Isomerase activityIEAmolecular_function
GO:0018279Protein N-linked glycosylation via asparagineTASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045454Cell redox homeostasisIEAbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75348042250.06803066370.99999024730.4927242641

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3174077307
GSE13712_SHEARDown-0.2631726437
GSE13712_STATICDown-0.0886055962
GSE19018Up0.4538773085
GSE19899_A1Down-0.8365868751
GSE19899_A2Down-0.8241153109
PubMed_21979375_A1Down-1.2215625811
PubMed_21979375_A2Down-1.0338679065
GSE35957Down-0.0178960406
GSE36640Up0.1890814315
GSE54402Down-0.3351915169
GSE9593Up0.3629905027
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.2833926603
GSE28863_A2Up0.4041297543
GSE28863_A3Down-0.1063918690
GSE28863_A4Up0.0876430786
GSE48662Up0.0553330614

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023749Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-7-5pMIMAT0000252MIRT025802SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23466301These genes, PDIA3, WDR1, FSTL1, COPG1, LMAN1, and PDIA6, significantly downregulated
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