HCSGD entry for SLC25A5
1. General information
| Official gene symbol | SLC25A5 |
|---|---|
| Entrez ID | 292 |
| Gene full name | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
| Other gene symbols | 2F1 AAC2 ANT2 T2 T3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006863 | Purine nucleobase transport | TAS | biological_process |
| GO:0007059 | Chromosome segregation | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0015207 | Adenine transmembrane transporter activity | TAS | molecular_function |
| GO:0015851 | Nucleobase transport | TAS | biological_process |
| GO:0015853 | Adenine transport | TAS | biological_process |
| GO:0015931 | Nucleobase-containing compound transport | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0071817 | MMXD complex | IDA | cellular_component |
| GO:1901029 | Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8645228867 | 0.1114017325 | 0.9999902473 | 0.6394347864 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0948905711 |
| GSE13712_SHEAR | Down | -0.2519666161 |
| GSE13712_STATIC | Down | -0.1289256394 |
| GSE19018 | Down | -0.5815434787 |
| GSE19899_A1 | Up | 0.0941096212 |
| GSE19899_A2 | Down | -0.0768540223 |
| PubMed_21979375_A1 | Down | -0.0734119245 |
| PubMed_21979375_A2 | Down | -0.2324122806 |
| GSE35957 | Down | -0.6348304292 |
| GSE36640 | Down | -0.5925170901 |
| GSE54402 | Up | 0.3961317356 |
| GSE9593 | Down | -0.4909028725 |
| GSE43922 | Up | 0.0061688081 |
| GSE24585 | Down | -0.0225413076 |
| GSE37065 | Down | -0.1975066241 |
| GSE28863_A1 | Up | 0.0088609327 |
| GSE28863_A2 | Up | 0.1888828314 |
| GSE28863_A3 | Up | 0.3538730693 |
| GSE28863_A4 | Up | 0.1778521651 |
| GSE48662 | Down | -0.6003838645 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-5p | MIMAT0004949 | MIRT037259 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040669 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044064 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044296 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046196 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047467 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047644 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050085 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3198 | MIMAT0015083 | MIRT052814 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25982278 | IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2 |
| 25982278 | Furthermore, the expression of adenine nucleotide translocase 2 (ANT2) was suppressed by IFNgamma contributing to elevation of ROS and DNA damage |
| 25982278 | Overall, our data reveal differences between cytokine effects in mouse and human cells, and mechanistically implicate the TGFbeta/SMAD pathway, via induction of NADPH oxidases and suppression of ANT2, as key mediators of IFNgamma/TNFalpha-evoked genotoxicity and cellular senescence |
| 25220407 | TGF-beta/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence |
| 25220407 | Here, we report that adenine nucleotide translocase-2 (ANT2) is consistently down-regulated in all three major forms of cellular senescence: replicative, oncogene-induced and drug-induced, in both normal and cancerous human cells |
| 25220407 | Mechanistically, binding of the NF1/Smad complexes to the NF1-dependent repressor elements in the ANT2 gene promoter repressed ANT2 expression |
| 25220407 | Etoposide-induced formation of these complexes and repression of ANT2 were relatively late events co-incident with production and secretion of, and dependent on, TGF-beta |
| 25220407 | Knock-down of ANT2, together with etoposide treatment, further intensified ROS production and DNA damage signaling, leading to enhanced apoptosis |
| 25220407 | Together, our data show that TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence |
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