HCSGD entry for GRM7

1. General information

Official gene symbolGRM7
Entrez ID2917
Gene full nameglutamate receptor, metabotropic 7
Other gene symbolsGLUR7 GPRC1G MGLU7 MGLUR7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001642Group III metabotropic glutamate receptor activityIDAmolecular_function
GO:0001661Conditioned taste aversionIEAbiological_process
GO:0001662Behavioral fear responseIEA IMPbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005245Voltage-gated calcium channel activityIEAmolecular_function
GO:0005246Calcium channel regulator activityIEAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007194Negative regulation of adenylate cyclase activityIDAbiological_process
GO:0007196Adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathwayIDAbiological_process
GO:0007268Synaptic transmissionIDA IEAbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0007608Sensory perception of smellIEAbiological_process
GO:0007614Short-term memoryIEAbiological_process
GO:0008066Glutamate receptor activityIDAmolecular_function
GO:0010855Adenylate cyclase inhibitor activityIDAmolecular_function
GO:0014050Negative regulation of glutamate secretionISSbiological_process
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0016595Glutamate bindingIDAmolecular_function
GO:0030165PDZ domain bindingNASmolecular_function
GO:0030424AxonISScellular_component
GO:0030425DendriteIDAcellular_component
GO:0030534Adult behaviorIEAbiological_process
GO:0030818Negative regulation of cAMP biosynthetic processIDAbiological_process
GO:0031279Regulation of cyclase activityIDAbiological_process
GO:0032279Asymmetric synapseISScellular_component
GO:0042734Presynaptic membraneIEAcellular_component
GO:0043198Dendritic shaftISScellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0045211Postsynaptic membraneISScellular_component
GO:0048786Presynaptic active zoneISScellular_component
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0070905Serine bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67896491770.93787843550.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0245020394
GSE13712_SHEARUp0.0725065058
GSE13712_STATICUp0.0899150391
GSE19018Up0.1000636356
GSE19899_A1Up0.0813479608
GSE19899_A2Up0.0707328214
PubMed_21979375_A1Up0.0231048391
PubMed_21979375_A2Up0.0621317474
GSE35957Up0.0864743002
GSE36640Up0.0244941332
GSE54402Up0.0965145779
GSE9593Down-0.0075820310
GSE43922Up0.0560295897
GSE24585Up0.0081950827
GSE37065Down-0.0492467233
GSE28863_A1Up0.0274765909
GSE28863_A2Up0.0339777384
GSE28863_A3Up0.1184653837
GSE28863_A4Up0.0218621964
GSE48662Down-0.0670330540

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT000073qRT-PCRFunctional MTI (Weak)20388499
hsa-miR-34a-5pMIMAT0000255MIRT000073Reporter assay;ProteomicsFunctional MTI21566225
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24755407We have recently described an Epigenetic-Senescence-Signature that facilitates prediction of the state of cellular aging by analysis of DNAm at six CpG sites (associated with the genes GRM7, CASR, PRAMEF2, SELP, CASP14 and KRTAP13-3), but this has not yet been proven over subsequent passages and with MSCs isolated under good manufacturing practice (GMP) conditions
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