HCSGD entry for UHRF1
1. General information
| Official gene symbol | UHRF1 |
|---|---|
| Entrez ID | 29128 |
| Gene full name | ubiquitin-like with PHD and ring finger domains 1 |
| Other gene symbols | ICBP90 Np95 RNF106 hNP95 hUHRF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000790 | Nuclear chromatin | IDA ISS | cellular_component |
| GO:0000791 | Euchromatin | IDA | cellular_component |
| GO:0000792 | Heterochromatin | IDA | cellular_component |
| GO:0000987 | Core promoter proximal region sequence-specific DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005657 | Replication fork | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0008283 | Cell proliferation | IEP | biological_process |
| GO:0008327 | Methyl-CpG binding | IDA | molecular_function |
| GO:0010216 | Maintenance of DNA methylation | IMP | biological_process |
| GO:0010390 | Histone monoubiquitination | ISS | biological_process |
| GO:0016363 | Nuclear matrix | ISS | cellular_component |
| GO:0016574 | Histone ubiquitination | IDA | biological_process |
| GO:0031493 | Nucleosomal histone binding | ISS | molecular_function |
| GO:0032270 | Positive regulation of cellular protein metabolic process | IDA | biological_process |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0042802 | Identical protein binding | ISS | molecular_function |
| GO:0044729 | Hemi-methylated DNA-binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IC | biological_process |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
| GO:2000373 | Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity | IC | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9221744615 | 0.0000638426 | 0.9999902473 | 0.0131281250 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.9814049238 |
| GSE13712_SHEAR | Up | 1.1610179644 |
| GSE13712_STATIC | Up | 0.3845389842 |
| GSE19018 | Down | -0.6969791654 |
| GSE19899_A1 | Down | -3.3391193964 |
| GSE19899_A2 | Down | -2.2285461263 |
| PubMed_21979375_A1 | Down | -2.1925945520 |
| PubMed_21979375_A2 | Down | -3.1442684915 |
| GSE35957 | Down | -4.3226265332 |
| GSE36640 | Down | -3.8882512045 |
| GSE54402 | Down | -0.1659752682 |
| GSE9593 | Down | -2.2544018611 |
| GSE43922 | Down | -0.5759774968 |
| GSE24585 | Down | -0.0534186843 |
| GSE37065 | Down | -0.4870540311 |
| GSE28863_A1 | Down | -0.0606152990 |
| GSE28863_A2 | Up | 0.0487202230 |
| GSE28863_A3 | Up | 0.5388766700 |
| GSE28863_A4 | Down | -0.0591093293 |
| GSE48662 | Down | -0.3753828054 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001324 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001580 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002574 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025268 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025268 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025644 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039881 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045790 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046925 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047494 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047656 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052615 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
