HCSGD entry for BRD7
1. General information
| Official gene symbol | BRD7 |
|---|---|
| Entrez ID | 29117 |
| Gene full name | bromodomain containing 7 |
| Other gene symbols | BP75 CELTIX1 NAG4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0035066 | Positive regulation of histone acetylation | IDA | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0070577 | Histone acetyl-lysine binding | IDA | molecular_function |
| GO:2000134 | Negative regulation of G1/S transition of mitotic cell cycle | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9819945367 | 0.0805497360 | 0.9999902473 | 0.5366108833 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0361429981 |
| GSE13712_SHEAR | Down | -0.0700782907 |
| GSE13712_STATIC | Down | -0.1611744799 |
| GSE19018 | Down | -0.1913007938 |
| GSE19899_A1 | Down | -0.1878417318 |
| GSE19899_A2 | Down | -0.3905301467 |
| PubMed_21979375_A1 | Down | -0.4062467245 |
| PubMed_21979375_A2 | Down | -0.4715733089 |
| GSE35957 | Down | -0.4637499680 |
| GSE36640 | Down | -0.3989050149 |
| GSE54402 | Down | -0.1300689598 |
| GSE9593 | Up | 0.0176195462 |
| GSE43922 | Down | -0.1546361216 |
| GSE24585 | Down | -0.0955755961 |
| GSE37065 | Up | 0.1920872000 |
| GSE28863_A1 | Up | 0.0167316130 |
| GSE28863_A2 | Down | -0.0392720148 |
| GSE28863_A3 | Up | 0.0223198613 |
| GSE28863_A4 | Down | -0.1476523655 |
| GSE48662 | Up | 0.0616392478 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200c-3p | MIMAT0000617 | MIRT006219 | Immunohistochemistry//Luciferase reporter assay//Microarray//Western blot | Functional MTI | 22015043 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036077 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037026 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048707 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26802028 | XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence |
| 26802028 | XAF1 expression was transcriptionally regulated by Bromodomain 7 (BRD7) |
| 26802028 | XAF1 induction with interferon-gamma (IFN-gamma) treatment was abrogated by BRD7 knockdown, which resulted in blocking interferon-induced senescence |
| 26802028 | In lung cancer cells, XAF1 tumor suppressor activity was decreased by BRD7 knockdown, and inhibition of tumor growth by IFN-gamma did not appear in BRD7-depleted xenograft tumors |
| 20660729 | Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence |
| 20660729 | Here we describe BRD7 and BAF180 as unique regulators of replicative senescence in human cells |
| 20660729 | Both regulate p53 transcriptional activity toward a subset of its target genes required for replicative and oncogenic stress senescence induction, and BRD7 physically interacts with p53 |
| 20660729 | BRD7 is a deletion target in human cancer, suggesting that loss of BRD7 may provide an additional mechanism to antagonize p53 function in cancer cells |
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