HCSGD entry for ARHGAP35

1. General information

Official gene symbolARHGAP35
Entrez ID2909
Gene full nameRho GTPase activating protein 35
Other gene symbolsGRF-1 GRLF1 P190-A P190A p190ARhoGAP p190RhoGAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001843Neural tube closureIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005634NucleusICcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0015629Actin cytoskeletonIEAcellular_component
GO:0030900Forebrain developmentIEAbiological_process
GO:0032320Positive regulation of Ras GTPase activityTASbiological_process
GO:0032321Positive regulation of Rho GTPase activityTASbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043116Negative regulation of vascular permeabilityIEAbiological_process
GO:0043547Positive regulation of GTPase activityTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36689530410.18980201360.99999024730.8444708925

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3177340722
GSE13712_SHEARUp0.0714543688
GSE13712_STATICUp0.0699773685
GSE19018Up0.2603071392
GSE19899_A1Down-0.2770962927
GSE19899_A2Down-0.2012729040
PubMed_21979375_A1Down-0.4456609224
PubMed_21979375_A2Down-0.1915704133
GSE35957Up0.0495300801
GSE36640Down-0.4149421727
GSE54402Down-0.0941610634
GSE9593Up0.1905805287
GSE43922Down-0.3041705456
GSE24585Up0.0483660217
GSE37065Down-0.4010660999
GSE28863_A1Up0.8892583527
GSE28863_A2Up0.7511579611
GSE28863_A3Up0.0043908059
GSE28863_A4Down-0.0718227225
GSE48662Up0.4157682120

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-3pMIMAT0004679MIRT038489CLASHFunctional MTI (Weak)23622248
hsa-miR-181b-5pMIMAT0000257MIRT047266CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.