HCSGD entry for PHPT1
1. General information
| Official gene symbol | PHPT1 |
|---|---|
| Entrez ID | 29085 |
| Gene full name | phosphohistidine phosphatase 1 |
| Other gene symbols | CGI-202 HSPC141 PHP14 RP11-216L13.10 bA216L13.10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004721 | Phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IDA | biological_process |
| GO:0008969 | Phosphohistidine phosphatase activity | IDA IMP | molecular_function |
| GO:0019855 | Calcium channel inhibitor activity | IDA | molecular_function |
| GO:0035774 | Positive regulation of insulin secretion involved in cellular response to glucose stimulus | IEA | biological_process |
| GO:0035971 | Peptidyl-histidine dephosphorylation | IDA | biological_process |
| GO:0044325 | Ion channel binding | IPI | molecular_function |
| GO:0050860 | Negative regulation of T cell receptor signaling pathway | IMP | biological_process |
| GO:0051350 | Negative regulation of lyase activity | IDA | biological_process |
| GO:2000147 | Positive regulation of cell motility | IMP | biological_process |
| GO:2000249 | Regulation of actin cytoskeleton reorganization | IMP | biological_process |
| GO:2000984 | Negative regulation of ATP citrate synthase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7889980396 | 0.0971229057 | 0.9999902473 | 0.5943668914 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2575067401 |
| GSE13712_SHEAR | Down | -0.2373531645 |
| GSE13712_STATIC | Down | -0.1091682456 |
| GSE19018 | Up | 0.3987731069 |
| GSE19899_A1 | Down | -0.8954306092 |
| GSE19899_A2 | Down | -0.3397707354 |
| PubMed_21979375_A1 | Up | 0.1925274623 |
| PubMed_21979375_A2 | Down | -0.2154672789 |
| GSE35957 | Down | -0.5162050693 |
| GSE36640 | Up | 0.4284733905 |
| GSE54402 | Down | -0.4590643610 |
| GSE9593 | Down | -0.0046686186 |
| GSE43922 | Down | -0.2111393642 |
| GSE24585 | Up | 0.2128187307 |
| GSE37065 | Down | -0.1990148372 |
| GSE28863_A1 | Down | -0.1417257313 |
| GSE28863_A2 | Down | -0.3055321913 |
| GSE28863_A3 | Up | 0.1174405885 |
| GSE28863_A4 | Up | 0.0851704131 |
| GSE48662 | Up | 0.1020371530 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023370 | Proteomics | Functional MTI (Weak) | 21750653 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037322 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047330 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048120 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
