HCSGD entry for NR3C1
1. General information
| Official gene symbol | NR3C1 |
|---|---|
| Entrez ID | 2908 |
| Gene full name | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| Other gene symbols | GCCR GCR GR GRL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004883 | Glucocorticoid receptor activity | IEA | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006111 | Regulation of gluconeogenesis | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA TAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008211 | Glucocorticoid metabolic process | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0030325 | Adrenal gland development | IEA | biological_process |
| GO:0031946 | Regulation of glucocorticoid biosynthetic process | IEA | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0060603 | Mammary gland duct morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5178900954 | 0.1816148513 | 0.9999902473 | 0.8263240277 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7374219626 |
| GSE13712_SHEAR | Up | 0.4402207903 |
| GSE13712_STATIC | Up | 0.3480440472 |
| GSE19018 | Down | -0.6147660689 |
| GSE19899_A1 | Up | 0.3952635958 |
| GSE19899_A2 | Down | -0.3687726708 |
| PubMed_21979375_A1 | Up | 0.2785454343 |
| PubMed_21979375_A2 | Down | -0.1210396397 |
| GSE35957 | Down | -0.0926402363 |
| GSE36640 | Down | -0.0570207349 |
| GSE54402 | Up | 0.2287991549 |
| GSE9593 | Down | -0.3113440842 |
| GSE43922 | Up | 0.0531700885 |
| GSE24585 | Up | 0.0254746668 |
| GSE37065 | Up | 0.0634253618 |
| GSE28863_A1 | Down | -0.0291461724 |
| GSE28863_A2 | Up | 0.0506680000 |
| GSE28863_A3 | Down | -0.3299049097 |
| GSE28863_A4 | Down | -0.1896714378 |
| GSE48662 | Up | 0.1891640470 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-5p | MIMAT0000072 | MIRT004545 | Luciferase reporter assay//Western blot//pMIR-REPORT | Functional MTI | 19131573 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT004546 | Luciferase reporter assay//Western blot//pMIR-REPORT//Northern blot | Functional MTI | 19131573 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT004546 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016193 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020164 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020725 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028300 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT030650 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031124 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-421 | MIMAT0003339 | MIRT039437 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
