HCSGD entry for SETD2

1. General information

Official gene symbolSETD2
Entrez ID29072
Gene full nameSET domain containing 2
Other gene symbolsHBP231 HIF-1 HIP-1 HYPB KMT3A SET2 p231HBP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001763Morphogenesis of a branching structureIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005694ChromosomeIEAcellular_component
GO:0006298Mismatch repairIMPbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterIMPbiological_process
GO:0010452Histone H3-K36 methylationIEAbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0010793Regulation of mRNA export from nucleusIMPbiological_process
GO:0018023Peptidyl-lysine trimethylationIEAbiological_process
GO:0018024Histone-lysine N-methyltransferase activityIDA IEA IMPmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0034728Nucleosome organizationIMPbiological_process
GO:0035441Cell migration involved in vasculogenesisIEAbiological_process
GO:0048332Mesoderm morphogenesisIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0048864Stem cell developmentIEAbiological_process
GO:0060039Pericardium developmentIEAbiological_process
GO:0060669Embryonic placenta morphogenesisIEAbiological_process
GO:0060977Coronary vasculature morphogenesisIEAbiological_process
GO:0097198Histone H3-K36 trimethylationIDA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93756486460.02654532120.99999024730.3120562834

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2485661502
GSE13712_SHEARUp0.2291764274
GSE13712_STATICUp0.0286264772
GSE19018Down-0.0703658246
GSE19899_A1Down-0.2643091906
GSE19899_A2Down-0.7004464381
PubMed_21979375_A1Down-0.2842737111
PubMed_21979375_A2Down-0.4667318906
GSE35957Down-0.1187016453
GSE36640Down-1.0272263804
GSE54402Down-0.2898924558
GSE9593Down-0.0851793439
GSE43922Down-0.4700483195
GSE24585Up0.1852301017
GSE37065Up0.1063207345
GSE28863_A1Up0.6391073058
GSE28863_A2Up0.2949538171
GSE28863_A3Down-0.4375945485
GSE28863_A4Down-0.2912343791
GSE48662Down-0.4898323013

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106b-5pMIMAT0000680MIRT044337CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050126CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24607280Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells
24607280Here, we show the antagonistic role of Set2 methyltransferase, which is specific for histone H3 at lysine 36, in regulating telomeric silencing and cellular lifespan
24607280We found that Set2 suppresses the restoration of unstable ON telomeres to the stable OFF state and promotes cellular aging
24607280Our results suggest that the accumulation of unstable ON telomeres maintained by Set2 is one of the features of aged cells
24496328Here we discuss that the mTOR pathway can cause cellular pseudo-hypoxic state, manifested by HIF-1 expression and lactate production under normoxia
24496328We found that rapamycin decreased HIF-1 and lactate levels in proliferating and senescent cells in vitro
23427299Further metabolic assays revealed significantly impaired mitochondrial function and hyperactive glycolysis, which were concomitant with the upregulation of HIF-1 and Hsp70
23119050Hypoxia and p38-MAPK are associated with inflammation, and hypoxia inducible factor 1 (HIF-1) has been detected in inflamed tissues
23119050We aimed to analyse the role of p38-MAPK and HIF-1 in the transcriptional regulation of CD36, a class B scavenger receptor, and its ligand thrombospondin (TSP-1) in macrophages and to evaluate the involvement of this pathway in phagocytosis of apoptotic neutrophils
23119050Transient transfection of macrophages with a miHIF-1alpha-targeting vector blocked the increase in mRNA expression of CD36 and TSP-1 during hypoxia and reduced phagocytosis, thus highlighting a role for the transcriptional activity of HIF-1
23119050Moreover, they suggest that CD36 expression in the damaged mucosa of patients with inflammatory bowel disease depends on p38-MAPK and HIF-1 activity
22958206Greater tolerance to hypoxia in older progenitor cells, as evidenced by elevated HIF-1 promoter reporter activity and hypoxia response gene (HRG) expression, mirrors the upregulation of HRGs in cohorts of older vs
22340562Expression of OPN, hypoxia inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) proteins was analyzed by Western blotting analysis
22340562RESULTS: HIF-1 and VEGF proteins in MDA-MB-343 cells were significantly downregulated upon the efficient knockdown of OPN expression under either hypoxia or normoxia environment
19584087In association with these phenotypic changes and the absence of HIF-1 alpha protein expression, we have demonstrated significant increases in global levels of DNA methylation and H3K9 histone acetylation in these cells, concomitant with the increased expression of DNA methyltransferase DMNT3b and gene-specific changes in DNA methylation at key imprinting loci
16161047This was invoked through the negative regulation of HIF-1 expression
161610471q, and our observation could open the new aspect in exploring the machinery of senescence induction associated with HIF-1 signal transduction
16161047These results also suggested the availability of negative regulation of HIF-1 signals for uterine cancer treatment, especially for uterine sarcomas that have worse prognosis and show a high frequency of EGLN1 gene abnormality
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