HCSGD entry for GRIN2C

1. General information

Official gene symbolGRIN2C
Entrez ID2905
Gene full nameglutamate receptor, ionotropic, N-methyl D-aspartate 2C
Other gene symbolsGluN2C NMDAR2C NR2C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004970Ionotropic glutamate receptor activityIEAmolecular_function
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityIEAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005261Cation channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0007215Glutamate receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0009611Response to woundingIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0033058Directional locomotionIEAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042177Negative regulation of protein catabolic processIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54451485130.90880464270.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0332626627
GSE13712_SHEARUp0.0186254878
GSE13712_STATICDown-0.0716656961
GSE19018Down-0.0404653950
GSE19899_A1Up0.0403539162
GSE19899_A2Up0.0336235870
PubMed_21979375_A1Down-0.0238926123
PubMed_21979375_A2Down-0.1095591264
GSE35957Up0.1933495479
GSE36640Up0.0332983659
GSE54402Up0.0354917938
GSE9593Up0.0896437178
GSE43922Up0.0983532718
GSE24585Up0.0548785640
GSE37065Down-0.0978666674
GSE28863_A1Down-0.1187991914
GSE28863_A2Down-0.0518201049
GSE28863_A3Up0.3692277651
GSE28863_A4Up0.1022157196
GSE48662Up0.3676681613

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
GlycineDB00145 NUTR00028
PethidineDB00454 APRD00074
TenocyclidineDB01520 -
AcamprosateDB00659 APRD00661
GavestinelDB06741 -
AtomoxetineDB00289 APRD00614
PentobarbitalDB00312 APRD01174
GabapentinDB00996 APRD00015
DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
MilnacipranDB04896 -
KetobemidoneDB06738 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.