HCSGD entry for GRIN2B

1. General information

Official gene symbolGRIN2B
Entrez ID2904
Gene full nameglutamate receptor, ionotropic, N-methyl D-aspartate 2B
Other gene symbolsGluN2B MRD6 NMDAR2B NR2B hNR3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001662Behavioral fear responseIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001964Startle responseIEAbiological_process
GO:0001967Suckling behaviorIEAbiological_process
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityIEAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005262Calcium channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0007215Glutamate receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007423Sensory organ developmentIEAbiological_process
GO:0007611Learning or memoryTASbiological_process
GO:0007612LearningIEAbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008270Zinc ion bindingISSmolecular_function
GO:0009986Cell surfaceISScellular_component
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016594Glycine bindingIDAmolecular_function
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIDAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0035235Ionotropic glutamate receptor signaling pathwayTASbiological_process
GO:0043005Neuron projectionISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045471Response to ethanolIDAbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048266Behavioral response to painIEAbiological_process
GO:0050966Detection of mechanical stimulus involved in sensory perception of painIEAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78274021500.73962248770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0720513081
GSE13712_SHEARUp0.0316638667
GSE13712_STATICUp0.0881848042
GSE19018Up0.0225468733
GSE19899_A1Up0.0670350533
GSE19899_A2Up0.1474128803
PubMed_21979375_A1Up0.0379281465
PubMed_21979375_A2Up0.0410353837
GSE35957Up0.0903068164
GSE36640Up0.0546475711
GSE54402Up0.0396104094
GSE9593Down-0.0270332807
GSE43922Up0.1843696194
GSE24585Down-0.0867577028
GSE37065Down-0.0848175007
GSE28863_A1Down-0.2417817598
GSE28863_A2Down-0.1094341392
GSE28863_A3Down-0.0131595128
GSE28863_A4Up0.0338053606
GSE48662Up0.0402843990

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
PethidineDB00454 APRD00074
FelbamateDB00949 APRD00505
MemantineDB01043 APRD00221
TenocyclidineDB01520 -
IfenprodilDB08954 -
AcamprosateDB00659 APRD00661
GavestinelDB06741 -
AtomoxetineDB00289 APRD00614
PentobarbitalDB00312 APRD01174
GabapentinDB00996 APRD00015
DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
MilnacipranDB04896 -
KetobemidoneDB06738 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.