HCSGD entry for GRIN2A

1. General information

Official gene symbolGRIN2A
Entrez ID2903
Gene full nameglutamate receptor, ionotropic, N-methyl D-aspartate 2A
Other gene symbolsEPND GluN2A NMDAR2A NR2A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001964Startle responseIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0004970Ionotropic glutamate receptor activityIEAmolecular_function
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityIEAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005262Calcium channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0007215Glutamate receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007611Learning or memoryTASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008104Protein localizationIEAbiological_process
GO:0008270Zinc ion bindingISSmolecular_function
GO:0008542Visual learningIEAbiological_process
GO:0009611Response to woundingIEAbiological_process
GO:0009986Cell surfaceISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIDAcellular_component
GO:0019233Sensory perception of painIEAbiological_process
GO:0022008NeurogenesisIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030431SleepIEAbiological_process
GO:0033058Directional locomotionIEAbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayTASbiological_process
GO:0042177Negative regulation of protein catabolic processIEAbiological_process
GO:0042417Dopamine metabolic processIEAbiological_process
GO:0042428Serotonin metabolic processIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045471Response to ethanolIDAbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0051930Regulation of sensory perception of painIEAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0097481Neuronal postsynaptic densityIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52605511190.88093012420.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2153487382
GSE13712_SHEARUp0.0052875490
GSE13712_STATICUp0.0166713318
GSE19018Up0.0416588192
GSE19899_A1Up0.0261990952
GSE19899_A2Down-0.0583752440
PubMed_21979375_A1Up0.2064985375
PubMed_21979375_A2Up0.0153738854
GSE35957Up0.0730506774
GSE36640Up0.0429810380
GSE54402Up0.1330938607
GSE9593Down-0.0620655147
GSE43922Up0.0115638150
GSE24585Up0.0138467879
GSE37065Up0.1106156972
GSE28863_A1Down-0.0503217083
GSE28863_A2Up0.3236683813
GSE28863_A3Down-0.0211246426
GSE28863_A4Down-0.1272417397
GSE48662Up0.1492920285

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
GlycineDB00145 NUTR00028
PethidineDB00454 APRD00074
FelbamateDB00949 APRD00505
MemantineDB01043 APRD00221
TenocyclidineDB01520 -
AcamprosateDB00659 APRD00661
GavestinelDB06741 -
AtomoxetineDB00289 APRD00614
PentobarbitalDB00312 APRD01174
GabapentinDB00996 APRD00015
DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
MilnacipranDB04896 -
KetobemidoneDB06738 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT004578Luciferase reporter assay//qRT-PCRFunctional MTI20159450
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.