HCSGD entry for GRIN1

1. General information

Official gene symbolGRIN1
Entrez ID2902
Gene full nameglutamate receptor, ionotropic, N-methyl D-aspartate 1
Other gene symbolsGluN1 MRD8 NMDA1 NMDAR1 NR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001661Conditioned taste aversionIEAbiological_process
GO:0001967Suckling behaviorIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0004970Ionotropic glutamate receptor activityIEAmolecular_function
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityIDAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005262Calcium channel activityIDAmolecular_function
GO:0005509Calcium ion bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingISSmolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006812Cation transportIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007585Respiratory gaseous exchangeIEAbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0008021Synaptic vesicleISScellular_component
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008355Olfactory learningIEAbiological_process
GO:0008542Visual learningISSbiological_process
GO:0009986Cell surfaceISScellular_component
GO:0014069Postsynaptic densityISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016594Glycine bindingIDA IMPmolecular_function
GO:0016595Glutamate bindingIDAmolecular_function
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIDAcellular_component
GO:0018964Propylene metabolic processISSbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0021586Pons maturationIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0022843Voltage-gated cation channel activityIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteIDAcellular_component
GO:0032590Dendrite membraneIEAcellular_component
GO:0035176Social behaviorIEAbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayISSbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0035254Glutamate receptor bindingIEAmolecular_function
GO:0042165Neurotransmitter bindingISSmolecular_function
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0043005Neuron projectionISScellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043083Synaptic cleftISScellular_component
GO:0043195Terminal boutonISScellular_component
GO:0043197Dendritic spineISScellular_component
GO:0043278Response to morphineIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043576Regulation of respiratory gaseous exchangeIEAbiological_process
GO:0045202SynapseISScellular_component
GO:0045211Postsynaptic membraneIEA ISScellular_component
GO:0045471Response to ethanolIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048169Regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0048511Rhythmic processIEAbiological_process
GO:0048814Regulation of dendrite morphogenesisIEAbiological_process
GO:0050770Regulation of axonogenesisIEAbiological_process
GO:0051262Protein tetramerizationIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0051963Regulation of synapse assemblyIEAbiological_process
GO:0055074Calcium ion homeostasisISSbiological_process
GO:0060076Excitatory synapseISScellular_component
GO:0060079Regulation of excitatory postsynaptic membrane potentialISSbiological_process
GO:0060134Prepulse inhibitionIEAbiological_process
GO:0060179Male mating behaviorIEAbiological_process
GO:0060992Response to fungicideIEAbiological_process
GO:0071287Cellular response to manganese ionIEAbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79146786980.87572853240.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1064159422
GSE13712_SHEARDown-0.1588475636
GSE13712_STATICUp0.0263203271
GSE19018Up0.0262768219
GSE19899_A1Up0.0162472886
GSE19899_A2Up0.0745013160
PubMed_21979375_A1Up0.0290318047
PubMed_21979375_A2Down-0.0624888625
GSE35957Up0.0583004360
GSE36640Up0.0647029838
GSE54402Down-0.0062056163
GSE9593Down-0.0271264616
GSE43922Up0.0467085375
GSE24585Down-0.0385906936
GSE37065Up0.1024531452
GSE28863_A1Down-0.0037245282
GSE28863_A2Up0.0839353820
GSE28863_A3Up0.2460560381
GSE28863_A4Up0.0485890079
GSE48662Up0.0305401219

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
PethidineDB00454 APRD00074
MemantineDB01043 APRD00221
Dcka, 5,7-Dichlorokynurenic AcidDB01931 EXPT01212
D-SerineDB03929 EXPT01275
CycloleucineDB04620 -
CNS-5161DB05824 -
AgmatineDB08838 -
IfenprodilDB08954 -
AcamprosateDB00659 APRD00661
GavestinelDB06741 -
AtomoxetineDB00289 APRD00614
PentobarbitalDB00312 APRD01174
GabapentinDB00996 APRD00015
DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
MilnacipranDB04896 -
KetobemidoneDB06738 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.