HCSGD entry for GRIK5

1. General information

Official gene symbolGRIK5
Entrez ID2901
Gene full nameglutamate receptor, ionotropic, kainate 5
Other gene symbolsEAA2 GRIK2 GluK5 KA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006621Protein retention in ER lumenIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015277Kainate selective glutamate receptor activityIDAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0030425DendriteIEAcellular_component
GO:0031630Regulation of synaptic vesicle fusion to presynaptic membraneIEAbiological_process
GO:0032983Kainate selective glutamate receptor complexIEAcellular_component
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayIDAbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0042802Identical protein bindingIEAmolecular_function
GO:0043113Receptor clusteringIEAbiological_process
GO:0043195Terminal boutonIEAcellular_component
GO:0043204PerikaryonIEAcellular_component
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051649Establishment of localization in cellIEAbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37396979600.92786935910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0070492440
GSE13712_SHEARUp0.1442148667
GSE13712_STATICDown-0.1108243669
GSE19018Up0.0991077278
GSE19899_A1Up0.1297989689
GSE19899_A2Up0.2050110447
PubMed_21979375_A1Up0.0236713256
PubMed_21979375_A2Up0.0029476802
GSE35957Up0.1985381373
GSE36640Up0.1046980644
GSE54402Up0.0241064859
GSE9593Down-0.0452585509
GSE43922Up0.0670150403
GSE24585Up0.0382138735
GSE37065Down-0.0584574834
GSE28863_A1Down-0.0743301191
GSE28863_A2Down-0.0112599460
GSE28863_A3Up0.4333092344
GSE28863_A4Up0.1466103953
GSE48662Up0.0948375240

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT045128CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.