HCSGD entry for HIPK2

1. General information

Official gene symbolHIPK2
Entrez ID28996
Gene full namehomeodomain interacting protein kinase 2
Other gene symbolsPRO0593
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityISSmolecular_function
GO:0001654Eye developmentISSbiological_process
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0010842Retina layer formationIEAbiological_process
GO:0016604Nuclear bodyIDA TAScellular_component
GO:0016605PML bodyIDAcellular_component
GO:0018105Peptidyl-serine phosphorylationISSbiological_process
GO:0018107Peptidyl-threonine phosphorylationISSbiological_process
GO:0019048Modulation by virus of host morphology or physiologyNASbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0030218Erythrocyte differentiationISSbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIMPbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIMPbiological_process
GO:0030578PML body organizationTASbiological_process
GO:0031965Nuclear membraneIDAcellular_component
GO:0032092Positive regulation of protein bindingISSbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorTASbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046332SMAD bindingIPImolecular_function
GO:0046790Virion bindingIPImolecular_function
GO:0048596Embryonic camera-type eye morphogenesisIEAbiological_process
GO:0050882Voluntary musculoskeletal movementIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0051726Regulation of cell cycleTASbiological_process
GO:0060059Embryonic retina morphogenesis in camera-type eyeIEAbiological_process
GO:0060235Lens induction in camera-type eyeIEAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0061072Iris morphogenesisIEAbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14045338320.58236378180.75280630721.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3223958279
GSE13712_SHEARUp0.1271230689
GSE13712_STATICDown-0.0148914726
GSE19018Down-0.3320309923
GSE19899_A1Down-0.3090729636
GSE19899_A2Down-0.1576369044
PubMed_21979375_A1Down-0.7235511721
PubMed_21979375_A2Down-0.0725617708
GSE35957Up0.6311367221
GSE36640Up0.4944876469
GSE54402Up0.1620569483
GSE9593Up0.2021990115
GSE43922Down-0.3734421232
GSE24585Up0.0714488852
GSE37065Up0.3115770274
GSE28863_A1Up0.2221615746
GSE28863_A2Up0.7228609352
GSE28863_A3Up0.1817965766
GSE28863_A4Down-0.1493964216
GSE48662Down-0.0945731583

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-27a-3pMIMAT0000084MIRT005357qRT-PCR//Western blotFunctional MTI20624637
hsa-miR-181a-5pMIMAT0000256MIRT005577Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21274007
hsa-miR-760MIMAT0004957MIRT036740CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038150CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038388CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040268CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040927CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045503CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046799CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047166CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.