HCSGD entry for GRIK3

1. General information

Official gene symbolGRIK3
Entrez ID2899
Gene full nameglutamate receptor, ionotropic, kainate 3
Other gene symbolsEAA5 GLR7 GLUR7 GluK3 GluR7a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001640Adenylate cyclase inhibiting G-protein coupled glutamate receptor activityIDAmolecular_function
GO:0004970Ionotropic glutamate receptor activityIDA IEA ISSmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007196Adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathwayIDAbiological_process
GO:0007215Glutamate receptor signaling pathwayIDAbiological_process
GO:0007216G-protein coupled glutamate receptor signaling pathwayIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008066Glutamate receptor activityTASmolecular_function
GO:0015277Kainate selective glutamate receptor activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030424AxonISScellular_component
GO:0030425DendriteISScellular_component
GO:0032839Dendrite cytoplasmISScellular_component
GO:0034220Ion transmembrane transportIDA ISSbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayIDA ISSbiological_process
GO:0042391Regulation of membrane potentialIDA ISSbiological_process
GO:0043195Terminal boutonISScellular_component
GO:0043204PerikaryonISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051967Negative regulation of synaptic transmission, glutamatergicISSbiological_process
GO:0055085Transmembrane transportIDA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55835806770.91157793780.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0085706110
GSE13712_SHEARUp0.1485809379
GSE13712_STATICUp0.1689835157
GSE19018Up0.0847750718
GSE19899_A1Up0.1514306860
GSE19899_A2Up0.1393913573
PubMed_21979375_A1Up0.0305102603
PubMed_21979375_A2Down-0.1266831170
GSE35957Up0.0256924433
GSE36640Down-0.0075629476
GSE54402Down-0.0153985315
GSE9593Up0.2018483743
GSE43922Up0.0214473926
GSE24585Down-0.0539127370
GSE37065Down-0.0161604069
GSE28863_A1Down-0.1385537141
GSE28863_A2Up0.0636190330
GSE28863_A3Up0.1487888850
GSE28863_A4Up0.0583790766
GSE48662Up0.1311050200

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.