HCSGD entry for GRIK2

1. General information

Official gene symbolGRIK2
Entrez ID2898
Gene full nameglutamate receptor, ionotropic, kainate 2
Other gene symbolsEAA4 GLR6 GLUK6 GLUR6 GluK2 MRT6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001662Behavioral fear responseIEAbiological_process
GO:0004970Ionotropic glutamate receptor activityIEAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportNASbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006886Intracellular protein transportIEAbiological_process
GO:0007215Glutamate receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0015277Kainate selective glutamate receptor activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0032983Kainate selective glutamate receptor complexIEAcellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0048169Regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0048172Regulation of short-term neuronal synaptic plasticityIEA IMPbiological_process
GO:0050804Regulation of synaptic transmissionIDAbiological_process
GO:0050806Positive regulation of synaptic transmissionIMPbiological_process
GO:0051967Negative regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0060080Regulation of inhibitory postsynaptic membrane potentialIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96095720530.01250873830.99999024730.2204719064

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2348469623
GSE13712_SHEARDown-0.0616004040
GSE13712_STATICDown-0.0040642796
GSE19018Up0.7287295695
GSE19899_A1Down-0.1917147042
GSE19899_A2Down-0.7907826568
PubMed_21979375_A1Down-0.5711599131
PubMed_21979375_A2Down-0.5342410331
GSE35957Up0.3280624987
GSE36640Down-0.8127152418
GSE54402Down-0.4070967599
GSE9593Up0.0677821278
GSE43922Down-1.2184847410
GSE24585Up0.0292477757
GSE37065Down-0.0255225514
GSE28863_A1Down-0.4318098832
GSE28863_A2Down-0.0627929415
GSE28863_A3Down-0.2663954086
GSE28863_A4Down-0.4436365842
GSE48662Down-0.1162921114

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
TalbutalDB00306 APRD01333
PentobarbitalDB00312 APRD01174
MetharbitalDB00463 APRD00757
PrimidoneDB00794 APRD00549
AmobarbitalDB01351 -
AprobarbitalDB01352 -
ButethalDB01353 -
HeptabarbitalDB01354 -
HexobarbitalDB01355 EXPT03301
BarbitalDB01483 -
Barbituric acid derivativeDB01496 -
Domoic AcidDB02852 EXPT01248
QuisqualateDB02999 EXPT02735
2s,4r-4-MethylglutamateDB03425 EXPT02986

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029019MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.