HCSGD entry for SPCS1

1. General information

Official gene symbolSPCS1
Entrez ID28972
Gene full namesignal peptidase complex subunit 1 homolog (S. cerevisiae)
Other gene symbolsSPC1 SPC12 YJR010C-A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003674Molecular_functionNDmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005787Signal peptidase complexIEA TAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006412TranslationTASbiological_process
GO:0006465Signal peptide processingIEAbiological_process
GO:0006508ProteolysisTASbiological_process
GO:0006614SRP-dependent cotranslational protein targeting to membraneTASbiological_process
GO:0008233Peptidase activityIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0043022Ribosome bindingIEAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56504032520.82733893850.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3090595668
GSE13712_SHEARDown-0.2099823672
GSE13712_STATICUp0.0211980700
GSE19018Up0.1793126333
GSE19899_A1Down-0.0210639532
GSE19899_A2Up0.0996885092
PubMed_21979375_A1Up0.1417434733
PubMed_21979375_A2Up0.0684876288
GSE35957Down-0.1360186017
GSE36640Up0.3721684140
GSE54402Down-0.0117709818
GSE9593Up0.0504876162
GSE43922Down-0.0048669256
GSE24585Up0.0134421958
GSE37065Up0.1147889821
GSE28863_A1Up0.0624818442
GSE28863_A2Up0.0833744415
GSE28863_A3Down-0.1181906584
GSE28863_A4Down-0.0149428973
GSE48662Down-0.1957023912

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020721ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.