HCSGD entry for GRIK1

1. General information

Official gene symbolGRIK1
Entrez ID2897
Gene full nameglutamate receptor, ionotropic, kainate 1
Other gene symbolsEAA3 EEA3 GLR5 GLUR5 GluK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004970Ionotropic glutamate receptor activityIEAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0007215Glutamate receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0014054Positive regulation of gamma-aminobutyric acid secretionIEAbiological_process
GO:0015277Kainate selective glutamate receptor activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0030534Adult behaviorIEAbiological_process
GO:0032230Positive regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0032983Kainate selective glutamate receptor complexIEAcellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayIDA TASbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0048266Behavioral response to painIEAbiological_process
GO:0051966Regulation of synaptic transmission, glutamatergicTASbiological_process
GO:0051967Negative regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0060080Regulation of inhibitory postsynaptic membrane potentialIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89736414270.75096101970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0524997606
GSE13712_SHEARDown-0.0287298486
GSE13712_STATICDown-0.0886044307
GSE19018Up0.1582641614
GSE19899_A1Up0.0582502712
GSE19899_A2Up0.0871779449
PubMed_21979375_A1Down-0.0846676888
PubMed_21979375_A2Up0.0278700874
GSE35957Up0.0630089980
GSE36640Down-0.2218773744
GSE54402Up0.0862773186
GSE9593Down-0.0400934649
GSE43922Up0.0108036838
GSE24585Down-0.1619269535
GSE37065Down-0.0507396163
GSE28863_A1Down-0.0237759307
GSE28863_A2Up0.0043174490
GSE28863_A3Up0.1341717814
GSE28863_A4Down-0.0233864954
GSE48662Down-0.0221958173

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
TopiramateDB00273 APRD00237

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.