HCSGD entry for GPX3
1. General information
| Official gene symbol | GPX3 |
|---|---|
| Entrez ID | 2878 |
| Gene full name | glutathione peroxidase 3 (plasma) |
| Other gene symbols | GPx-P GSHPx-3 GSHPx-P |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004602 | Glutathione peroxidase activity | IDA IEA | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0006982 | Response to lipid hydroperoxide | TAS | biological_process |
| GO:0008134 | Transcription factor binding | TAS | molecular_function |
| GO:0008430 | Selenium binding | IDA | molecular_function |
| GO:0042744 | Hydrogen peroxide catabolic process | TAS | biological_process |
| GO:0051289 | Protein homotetramerization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0109785798 | 0.0541018388 | 0.2646632784 | 0.4383556171 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.7992054653 |
| GSE13712_SHEAR | Down | -1.7590886914 |
| GSE13712_STATIC | Down | -1.8820268301 |
| GSE19018 | Up | 0.2854124264 |
| GSE19899_A1 | Down | -0.1013592772 |
| GSE19899_A2 | Down | -0.2237679469 |
| PubMed_21979375_A1 | Up | 0.5038360364 |
| PubMed_21979375_A2 | Down | -0.5201138776 |
| GSE35957 | Down | -1.7781629646 |
| GSE36640 | Up | 2.3568403883 |
| GSE54402 | Up | 0.6111092153 |
| GSE9593 | Up | 0.4835949933 |
| GSE43922 | Down | -0.5198442432 |
| GSE24585 | Up | 1.2497196203 |
| GSE37065 | Up | 0.7461430046 |
| GSE28863_A1 | Down | -0.1081836152 |
| GSE28863_A2 | Up | 0.0388463979 |
| GSE28863_A3 | Up | 0.0151633782 |
| GSE28863_A4 | Down | -0.0345955975 |
| GSE48662 | Up | 0.6187063150 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049503 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26340803 | The relationship of SOD and GPx3 was analyzed in the two groups |
| 26340803 | A significant negative correlation between GPx3 and SOD activity was identified in DS (r=-0 |
| 26340803 | Reducing GPx3 may be a compensatory mechanism of protection against intracellular OS |
| 26340803 | Moreover, monitoring of decreases in GPx3 activity may be a useful biomarker for evaluating OS in DS patients |
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