HCSGD entry for MKNK2
1. General information
| Official gene symbol | MKNK2 |
|---|---|
| Entrez ID | 2872 |
| Gene full name | MAP kinase interacting serine/threonine kinase 2 |
| Other gene symbols | GPRK7 MNK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0030097 | Hemopoiesis | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0071243 | Cellular response to arsenic-containing substance | IDA | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0045355420 | 0.9410061396 | 0.1782794074 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4478609408 |
| GSE13712_SHEAR | Down | -0.3682679268 |
| GSE13712_STATIC | Down | -0.0079580089 |
| GSE19018 | Up | 1.0460485297 |
| GSE19899_A1 | Up | 0.6865513926 |
| GSE19899_A2 | Up | 1.5525735609 |
| PubMed_21979375_A1 | Up | 0.8347681391 |
| PubMed_21979375_A2 | Up | 1.3244466948 |
| GSE35957 | Down | -0.4352321846 |
| GSE36640 | Up | 0.5701506436 |
| GSE54402 | Up | 0.0542709365 |
| GSE9593 | Up | 0.2537261737 |
| GSE43922 | Up | 0.5468767451 |
| GSE24585 | Up | 0.3776097497 |
| GSE37065 | Down | -0.5568553315 |
| GSE28863_A1 | Up | 0.2479349933 |
| GSE28863_A2 | Down | -0.1607541707 |
| GSE28863_A3 | Up | 0.1688484748 |
| GSE28863_A4 | Up | 0.0184318631 |
| GSE48662 | Up | 0.2059591990 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT003997 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017015 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021912 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027246 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027463 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028737 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030773 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035940 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038052 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042931 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049249 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
