HCSGD entry for GRK6
1. General information
| Official gene symbol | GRK6 |
|---|---|
| Entrez ID | 2870 |
| Gene full name | G protein-coupled receptor kinase 6 |
| Other gene symbols | GPRK6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004703 | G-protein coupled receptor kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0008277 | Regulation of G-protein coupled receptor protein signaling pathway | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0038032 | Termination of G-protein coupled receptor signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8972314008 | 0.2230235097 | 0.9999902473 | 0.9087372446 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1365165753 |
| GSE13712_SHEAR | Down | -0.0617887143 |
| GSE13712_STATIC | Up | 0.0951059132 |
| GSE19018 | Down | -0.0267878083 |
| GSE19899_A1 | Down | -0.0206211277 |
| GSE19899_A2 | Down | -0.1038881099 |
| PubMed_21979375_A1 | Up | 0.3421840995 |
| PubMed_21979375_A2 | Up | 0.1772731227 |
| GSE35957 | Down | -0.3275818646 |
| GSE36640 | Down | -0.3084414323 |
| GSE54402 | Up | 0.2068448073 |
| GSE9593 | Down | -0.3258598737 |
| GSE43922 | Up | 0.0488917811 |
| GSE24585 | Down | -0.5424194392 |
| GSE37065 | Down | -0.1355798231 |
| GSE28863_A1 | Down | -0.0690242774 |
| GSE28863_A2 | Down | -0.0319065952 |
| GSE28863_A3 | Up | 0.0409190099 |
| GSE28863_A4 | Up | 0.0059744184 |
| GSE48662 | Up | 0.0157866645 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-421 | MIMAT0003339 | MIRT039394 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039567 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-326 | MIMAT0000756 | MIRT043626 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044058 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044541 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT050646 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
