HCSGD entry for ANK2

1. General information

Official gene symbolANK2
Entrez ID287
Gene full nameankyrin 2, neuronal
Other gene symbolsANK-2 LQT4 brank-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002027Regulation of heart rateIMPbiological_process
GO:0003283Atrial septum developmentIMPbiological_process
GO:0005200Structural constituent of cytoskeletonIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIGIcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneISScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006874Cellular calcium ion homeostasisIEA ISSbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0010628Positive regulation of gene expressionIEA IGIbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIGI ISSbiological_process
GO:0010882Regulation of cardiac muscle contraction by calcium ion signalingIEA IMPbiological_process
GO:0014704Intercalated discIEA ISScellular_component
GO:0015459Potassium channel regulator activityIEAmolecular_function
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIEA IPImolecular_function
GO:0030018Z discIEA ISScellular_component
GO:0030315T-tubuleIEA ISScellular_component
GO:0030507Spectrin bindingIPImolecular_function
GO:0030674Protein binding, bridgingIEA ISSmolecular_function
GO:0030913Paranodal junction assemblyIEAbiological_process
GO:0031430M bandIEA ISScellular_component
GO:0031647Regulation of protein stabilityICbiological_process
GO:0031672A bandISScellular_component
GO:0033292T-tubule organizationIEA ISSbiological_process
GO:0033365Protein localization to organelleIGIbiological_process
GO:0034394Protein localization to cell surfaceIEA ISSbiological_process
GO:0034613Cellular protein localizationIGIbiological_process
GO:0036309Protein localization to M-bandIEA ISSbiological_process
GO:0036371Protein localization to T-tubuleIEA ISSbiological_process
GO:0042383SarcolemmaISScellular_component
GO:0043005Neuron projectionIEAcellular_component
GO:0043034CostamereIEA ISScellular_component
GO:0043268Positive regulation of potassium ion transportIEA ISSbiological_process
GO:0044325Ion channel bindingIEA IPI ISSmolecular_function
GO:0045121Membrane raftIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050821Protein stabilizationIEA ISSbiological_process
GO:0051117ATPase bindingIEA ISSmolecular_function
GO:0051279Regulation of release of sequestered calcium ion into cytosolIGIbiological_process
GO:0051597Response to methylmercuryIEAbiological_process
GO:0051924Regulation of calcium ion transportIGIbiological_process
GO:0051928Positive regulation of calcium ion transportIEA ISSbiological_process
GO:0055117Regulation of cardiac muscle contractionIMPbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0070296Sarcoplasmic reticulum calcium ion transportTASbiological_process
GO:0070972Protein localization to endoplasmic reticulumIEA IGIbiological_process
GO:0072659Protein localization to plasma membraneIGI ISSbiological_process
GO:0072661Protein targeting to plasma membraneIEAbiological_process
GO:0086004Regulation of cardiac muscle cell contractionIGIbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086014Atrial cardiac muscle cell action potentialIEA IMPbiological_process
GO:0086015SA node cell action potentialIEA ISSbiological_process
GO:0086036Regulation of cardiac muscle cell membrane potentialIEAbiological_process
GO:0086046Membrane depolarization during SA node cell action potentialTASbiological_process
GO:0086066Atrial cardiac muscle cell to AV node cell communicationISSbiological_process
GO:0086070SA node cell to atrial cardiac muscle cell communicationIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIEA IMP ISSbiological_process
GO:1901018Positive regulation of potassium ion transmembrane transporter activityIEA ISSbiological_process
GO:1901019Regulation of calcium ion transmembrane transporter activityISSbiological_process
GO:1901021Positive regulation of calcium ion transmembrane transporter activityIEA ISSbiological_process
GO:2001259Positive regulation of cation channel activityIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14690920560.72817994000.76807992061.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0330580924
GSE13712_SHEARDown-0.0716159877
GSE13712_STATICDown-0.0043430864
GSE19018Down-0.1726069733
GSE19899_A1Up0.0767620178
GSE19899_A2Down-0.1110814606
PubMed_21979375_A1Down-0.2609966873
PubMed_21979375_A2Up0.2812155293
GSE35957Up0.2738159179
GSE36640Up0.8344688071
GSE54402Down-0.2511049331
GSE9593Up0.9355401393
GSE43922Up0.0333892391
GSE24585Down-0.5265979357
GSE37065Up0.0260544506
GSE28863_A1Up0.3721362419
GSE28863_A2Up0.5526446655
GSE28863_A3Down-0.0336545897
GSE28863_A4Up0.0518313097
GSE48662Up0.1286112400

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT003081Luciferase reporter assay//qRT-PCRFunctional MTI19296470
hsa-miR-335-5pMIMAT0000765MIRT018205MicroarrayFunctional MTI (Weak)18185580
hsa-miR-877-3pMIMAT0004950MIRT037121CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.