HCSGD entry for ATP11C
1. General information
| Official gene symbol | ATP11C |
|---|---|
| Entrez ID | 286410 |
| Gene full name | ATPase, class VI, type 11C |
| Other gene symbols | ATPIG ATPIQ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0004012 | Phospholipid-translocating ATPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019829 | Cation-transporting ATPase activity | IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0045332 | Phospholipid translocation | NAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8777935147 | 0.0103399225 | 0.9999902473 | 0.2004076527 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3722628249 |
| GSE13712_SHEAR | Down | -0.1489262660 |
| GSE13712_STATIC | Down | -0.2085089353 |
| GSE19018 | Down | -0.3146877779 |
| GSE19899_A1 | Down | -0.6909174360 |
| GSE19899_A2 | Down | -0.8052928083 |
| PubMed_21979375_A1 | Down | -0.8017349639 |
| PubMed_21979375_A2 | Down | -0.5388852476 |
| GSE35957 | Up | 0.6493291391 |
| GSE36640 | Down | -0.9030963389 |
| GSE54402 | Down | -0.7314966876 |
| GSE9593 | Up | 0.2403255140 |
| GSE43922 | Down | -0.6130955253 |
| GSE24585 | Down | -0.5017068040 |
| GSE37065 | Down | -0.0103050345 |
| GSE28863_A1 | Up | 0.5288932339 |
| GSE28863_A2 | Up | 0.2622790809 |
| GSE28863_A3 | Down | -0.1729140859 |
| GSE28863_A4 | Up | 0.2865115509 |
| GSE48662 | Down | -0.3539134703 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003182 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021452 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039505 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26944472 | ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia |
| 26944472 | Herein, we report that ATP11C encodes a major flippase in human erythrocytes, and a genetic mutation identified in a male patient caused congenital hemolytic anemia inherited as an X-linked recessive trait |
| 26944472 | Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a major flippase in human erythrocytes |
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