HCSGD entry for NSMCE2
1. General information
| Official gene symbol | NSMCE2 |
|---|---|
| Entrez ID | 286053 |
| Gene full name | non-SMC element 2, MMS21 homolog (S. cerevisiae) |
| Other gene symbols | C8orf36 MMS21 NSE2 ZMIZ7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000722 | Telomere maintenance via recombination | IMP | biological_process |
| GO:0000724 | Double-strand break repair via homologous recombination | IEA IMP | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IMP | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0016925 | Protein sumoylation | IEA | biological_process |
| GO:0019789 | SUMO ligase activity | IDA IEA | molecular_function |
| GO:0030915 | Smc5-Smc6 complex | IDA IEA | cellular_component |
| GO:0034184 | Positive regulation of maintenance of mitotic sister chromatid cohesion | IMP | biological_process |
| GO:0045842 | Positive regulation of mitotic metaphase/anaphase transition | IMP | biological_process |
| GO:0090398 | Cellular senescence | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9141792827 | 0.0541392386 | 0.9999902473 | 0.4383847786 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1086698854 |
| GSE13712_SHEAR | Down | -0.5569099505 |
| GSE13712_STATIC | Down | -0.2023884420 |
| GSE19018 | Up | 0.3285406043 |
| GSE19899_A1 | Up | 0.0248841171 |
| GSE19899_A2 | Down | -0.4293166353 |
| PubMed_21979375_A1 | Up | 0.3919044197 |
| PubMed_21979375_A2 | Down | -0.2659978894 |
| GSE35957 | Down | -0.3573185257 |
| GSE36640 | Down | -0.6529249912 |
| GSE54402 | Down | -0.0297898864 |
| GSE9593 | Up | 0.2387033964 |
| GSE43922 | Up | 0.0366402501 |
| GSE24585 | Up | 0.0299350303 |
| GSE37065 | Up | 0.0856421678 |
| GSE28863_A1 | Down | -0.0918087242 |
| GSE28863_A2 | Down | -0.3689302411 |
| GSE28863_A3 | Down | -0.4776064048 |
| GSE28863_A4 | Down | -0.0736854961 |
| GSE48662 | Down | -0.4145134395 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20159973 | We identify Mms21 as the relevant SUMO E3 ligase and demonstrate that cells lacking Mms21-dependent sumoylation accumulate HR intermediates selectively at telomeres during senescence |
| 20159973 | Further, we provide evidence that Mms21 and Smc5/6 prevent aberrant recombination between sister telomeres and also globally facilitate resolution of sister chromatid HR intermediates |
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