HCSGD entry for IFNL1

1. General information

Official gene symbolIFNL1
Entrez ID282618
Gene full nameinterferon, lambda 1
Other gene symbolsIL-29 IL29
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002829Negative regulation of type 2 immune responseIDAbiological_process
GO:0005102Receptor bindingIDAmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0032002Interleukin-28 receptor complexIDAcellular_component
GO:0032003Interleukin-28 receptor bindingIPImolecular_function
GO:0032696Negative regulation of interleukin-13 productionIDAbiological_process
GO:0032714Negative regulation of interleukin-5 productionIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIDAbiological_process
GO:0042531Positive regulation of tyrosine phosphorylation of STAT proteinIDAbiological_process
GO:0043381Negative regulation of memory T cell differentiationIDAbiological_process
GO:0045345Positive regulation of MHC class I biosynthetic processIDAbiological_process
GO:0045581Negative regulation of T cell differentiationIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0050778Positive regulation of immune responseTASbiological_process
GO:0051607Defense response to virusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42687597360.79329055890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1333181036
GSE13712_SHEARDown-0.0268833198
GSE13712_STATICUp0.0244611776
GSE19018Down-0.1693930986
GSE19899_A1Down-0.0050094225
GSE19899_A2Up0.1257536729
PubMed_21979375_A1Down-0.0521226872
PubMed_21979375_A2Up0.1032064532
GSE35957Up0.2436211123
GSE36640Up0.0905956281
GSE54402Down-0.0709626158
GSE9593Up0.2014243314
GSE43922Up0.0347428083
GSE24585Up0.1296996149
GSE37065Up0.1085745459
GSE28863_A1Down-0.1134905273
GSE28863_A2Down-0.0058028966
GSE28863_A3Up0.3220785789
GSE28863_A4Up0.1468526525
GSE48662Down-0.0145916253

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25466460The SPR biosensor also shows specificity for IGFBP7 compared to that for biologically relevant interleukin (IL) derivatives including IL4, IL23, IL29, and IFG1
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