HCSGD entry for GOT1

1. General information

Official gene symbolGOT1
Entrez ID2805
Gene full nameglutamic-oxaloacetic transaminase 1, soluble
Other gene symbolsASTQTL1 GIG18 cAspAT cCAT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000096Sulfur amino acid metabolic processTASbiological_process
GO:0004069L-aspartate:2-oxoglutarate aminotransferase activityIDA IEA ISS TASmolecular_function
GO:0004609Phosphatidylserine decarboxylase activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006094GluconeogenesisTASbiological_process
GO:00061032-oxoglutarate metabolic processISSbiological_process
GO:0006107Oxaloacetate metabolic processIEAbiological_process
GO:0006114Glycerol biosynthetic processISSbiological_process
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006531Aspartate metabolic processISSbiological_process
GO:0006532Aspartate biosynthetic processIEAbiological_process
GO:0006533Aspartate catabolic processIDAbiological_process
GO:0006536Glutamate metabolic processISSbiological_process
GO:0006595Polyamine metabolic processTASbiological_process
GO:0008483Transaminase activityTASmolecular_function
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0009058Biosynthetic processIEAbiological_process
GO:0019509L-methionine salvage from methylthioadenosineTASbiological_process
GO:0019550Glutamate catabolic process to aspartateIEAbiological_process
GO:0019551Glutamate catabolic process to 2-oxoglutarateIEAbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0031406Carboxylic acid bindingIEAmolecular_function
GO:0032869Cellular response to insulin stimulusIEPbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047801L-cysteine:2-oxoglutarate aminotransferase activityISSmolecular_function
GO:0051384Response to glucocorticoidIEPbiological_process
GO:0055089Fatty acid homeostasisIEAbiological_process
GO:0080130L-phenylalanine:2-oxoglutarate aminotransferase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57958975720.11104492610.99999024730.6383082551

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2551536083
GSE13712_SHEARDown-0.1543142278
GSE13712_STATICDown-0.2332325154
GSE19018Up0.6539294808
GSE19899_A1Down-0.2819842808
GSE19899_A2Down-0.3469611496
PubMed_21979375_A1Up0.3864431368
PubMed_21979375_A2Down-0.6305843788
GSE35957Down-0.7621578223
GSE36640Down-0.4970547003
GSE54402Down-0.2074647413
GSE9593Up0.0534404775
GSE43922Down-0.0582768165
GSE24585Up0.2716869983
GSE37065Down-0.1106199458
GSE28863_A1Up0.0096155973
GSE28863_A2Down-0.2248001393
GSE28863_A3Down-0.3310311547
GSE28863_A4Up0.1907690311
GSE48662Up0.1979938813

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
L-Glutamic AcidDB00142 NUTR00027
L-CysteineDB00151 NUTR00018 | DB04443
Maleic AcidDB04299 EXPT02106

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-769-5pMIMAT0003886MIRT039193CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.