HCSGD entry for GNRH1
1. General information
| Official gene symbol | GNRH1 |
|---|---|
| Entrez ID | 2796 |
| Gene full name | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
| Other gene symbols | GNRH GRH HH12 LHRH LNRH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005179 | Hormone activity | TAS | molecular_function |
| GO:0005183 | Gonadotropin hormone-releasing hormone activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0031960 | Response to corticosteroid | IEA | biological_process |
| GO:0042698 | Ovulation cycle | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:2000354 | Regulation of ovarian follicle development | IEA | biological_process |
| GO:2001223 | Negative regulation of neuron migration | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7069288781 | 0.1484458227 | 0.9999902473 | 0.7453724723 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1098613898 |
| GSE13712_SHEAR | Down | -0.0717115796 |
| GSE13712_STATIC | Down | -0.1051071393 |
| GSE19018 | Up | 0.0243036996 |
| GSE19899_A1 | Up | 0.0848953953 |
| GSE19899_A2 | Down | -0.7509978558 |
| PubMed_21979375_A1 | Down | -0.6093249106 |
| PubMed_21979375_A2 | Down | -0.5437380630 |
| GSE35957 | Down | -0.0206923251 |
| GSE36640 | Up | 0.1420349202 |
| GSE54402 | Down | -0.7153847219 |
| GSE9593 | Up | 0.0365888588 |
| GSE43922 | Up | 0.0113509018 |
| GSE24585 | Down | -0.1900146672 |
| GSE37065 | Down | -0.0437812627 |
| GSE28863_A1 | Up | 0.4872069006 |
| GSE28863_A2 | Up | 0.2853100203 |
| GSE28863_A3 | Down | -0.2152303160 |
| GSE28863_A4 | Up | 0.0150685664 |
| GSE48662 | Up | 0.0991334154 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024742 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026258 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24476133 | Current medical treatments with GnRH analogs do not provide long-term benefit |
| 24112790 | Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice |
| 24112790 | Kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) play a key role in relaying the positive feedback effects of estradiol that activate gonadotropin-releasing hormone (GnRH) neurons and drive a surge in the GnRH/luteinizing hormone (LH) level |
| 24112790 | Focusing on middle-aged intact female mice with irregular estrous cycles, we found a parallel decline in c-Fos-positive kisspeptin neurons and c-Fos-positive GnRH neurons at the time of the GnRH/LH surge |
| 24112790 | Interestingly, some kisspeptin neurons in the RP3V, but none of the GnRH neurons in the rostral preoptic area (rPOA), had a characteristic cellular senescence in middle-aged mice and old mice |
| 10811143 | Coincubation of thymulin with the secretagogue gonadotropin-releasing hormone (GnRH) revealed a synergistic effect on LH release and an additive effect on the release of FSH |
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