HCSGD entry for GNAS

1. General information

Official gene symbolGNAS
Entrez ID2778
Gene full nameGNAS complex locus
Other gene symbolsAHO C20orf45 GNAS1 GPSA GSA GSP NESP PHP1A PHP1B PHP1C POH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIEAcellular_component
GO:0001894Tissue homeostasisIEAbiological_process
GO:0001958Endochondral ossificationIEAbiological_process
GO:0003674Molecular_functionNDmolecular_function
GO:0003924GTPase activityIBA IEA TASmolecular_function
GO:0004016Adenylate cyclase activityTASmolecular_function
GO:0004871Signal transducer activityIBA IDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolISScellular_component
GO:0005834Heterotrimeric G-protein complexIBA ISS TAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006112Energy reserve metabolic processIEA TASbiological_process
GO:0006171CAMP biosynthetic processTASbiological_process
GO:0006306DNA methylationIEAbiological_process
GO:0006833Water transportTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007191Adenylate cyclase-activating dopamine receptor signaling pathwayIBA IEA ISSbiological_process
GO:0007565Female pregnancyNASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007606Sensory perception of chemical stimulusIBAbiological_process
GO:0007608Sensory perception of smellTASbiological_process
GO:0009306Protein secretionNASbiological_process
GO:0016020MembraneIEA ISScellular_component
GO:0030133Transport vesicleIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031224Intrinsic component of membraneIDAcellular_component
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIBAcellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIBA IEAmolecular_function
GO:0031852Mu-type opioid receptor bindingIBAmolecular_function
GO:0032320Positive regulation of Ras GTPase activityIDAbiological_process
GO:0032588Trans-Golgi network membraneIDAcellular_component
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035255Ionotropic glutamate receptor bindingIBAmolecular_function
GO:0035264Multicellular organism growthIEAbiological_process
GO:0040032Post-embryonic body morphogenesisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043588Skin developmentIEAbiological_process
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045672Positive regulation of osteoclast differentiationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046907Intracellular transportNASbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:0071380Cellular response to prostaglandin E stimulusISSbiological_process
GO:0071514Genetic imprintingIEAbiological_process
GO:0071870Cellular response to catecholamine stimulusISSbiological_process
GO:0071880Adenylate cyclase-activating adrenergic receptor signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94031431560.39005771820.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0197530332
GSE13712_SHEARUp0.0842140153
GSE13712_STATICDown-0.1494152885
GSE19018Up0.2353247141
GSE19899_A1Down-0.1391949783
GSE19899_A2Down-0.0107911626
PubMed_21979375_A1Down-0.5222504591
PubMed_21979375_A2Up0.0632453947
GSE35957Down-0.0740460476
GSE36640Down-0.0542057895
GSE54402Down-0.1449099628
GSE9593Down-0.0280988981
GSE43922Down-0.1971831838
GSE24585Up0.1558312355
GSE37065Down-0.0702804322
GSE28863_A1Down-0.0632512207
GSE28863_A2Down-0.1752523114
GSE28863_A3Up0.0356299123
GSE28863_A4Up0.0317626575
GSE48662Down-0.0381557084

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ColforsinDB02587 EXPT01467
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATEDB06843 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020904ProteomicsFunctional MTI (Weak)18668040
hsa-miR-320bMIMAT0005792MIRT036192CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039683CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040832CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042911CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043309CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044478CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051047CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052019CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.