HCSGD entry for GNAL
1. General information
| Official gene symbol | GNAL |
|---|---|
| Entrez ID | 2774 |
| Gene full name | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type |
| Other gene symbols | DYT25 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IBA | molecular_function |
| GO:0001975 | Response to amphetamine | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IBA IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005834 | Heterotrimeric G-protein complex | IBA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007189 | Adenylate cyclase-activating G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007190 | Activation of adenylate cyclase activity | IEA | biological_process |
| GO:0007191 | Adenylate cyclase-activating dopamine receptor signaling pathway | IBA IEA | biological_process |
| GO:0007193 | Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007608 | Sensory perception of smell | IBA IEA | biological_process |
| GO:0031000 | Response to caffeine | IEA | biological_process |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IBA | cellular_component |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7355539911 | 0.1592230158 | 0.9999902473 | 0.7708127644 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1429806485 |
| GSE13712_SHEAR | Down | -0.1239888185 |
| GSE13712_STATIC | Down | -0.0689647924 |
| GSE19018 | Down | -0.0564002485 |
| GSE19899_A1 | Down | -0.0380588720 |
| GSE19899_A2 | Down | -0.0894310433 |
| PubMed_21979375_A1 | Down | -0.0240641402 |
| PubMed_21979375_A2 | Up | 0.4609356932 |
| GSE35957 | Down | -0.2272423347 |
| GSE36640 | Up | 0.3164157190 |
| GSE54402 | Down | -0.6985874431 |
| GSE9593 | Down | -0.2993431066 |
| GSE43922 | Up | 0.3685975745 |
| GSE24585 | Down | -1.2080304749 |
| GSE37065 | Down | -0.0022477851 |
| GSE28863_A1 | Down | -0.0039499061 |
| GSE28863_A2 | Down | -0.0310051469 |
| GSE28863_A3 | Up | 0.1970332428 |
| GSE28863_A4 | Up | 0.0064551268 |
| GSE48662 | Up | 0.0091029812 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047629 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048626 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051131 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
