HCSGD entry for GNAI2
1. General information
| Official gene symbol | GNAI2 |
|---|---|
| Entrez ID | 2771 |
| Gene full name | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| Other gene symbols | GIP GNAI2B H_LUCA15.1 H_LUCA16.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IEA | biological_process |
| GO:0001664 | G-protein coupled receptor binding | IBA | molecular_function |
| GO:0001973 | Adenosine receptor signaling pathway | IBA IEA | biological_process |
| GO:0003924 | GTPase activity | IBA IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IBA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005834 | Heterotrimeric G-protein complex | IBA | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA TAS | biological_process |
| GO:0007188 | Adenylate cyclase-modulating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007193 | Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007194 | Negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway | IEA | biological_process |
| GO:0007214 | Gamma-aminobutyric acid signaling pathway | IBA IEA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007584 | Response to nutrient | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0019001 | Guanyl nucleotide binding | IEA | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IBA | cellular_component |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA IEA | molecular_function |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050805 | Negative regulation of synaptic transmission | IEA | biological_process |
| GO:0051301 | Cell division | IMP | biological_process |
| GO:0051924 | Regulation of calcium ion transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6495387029 | 0.3297155617 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0059234847 |
| GSE13712_SHEAR | Up | 0.1015634461 |
| GSE13712_STATIC | Down | -0.1891730747 |
| GSE19018 | Up | 0.3182629409 |
| GSE19899_A1 | Down | -0.2831356862 |
| GSE19899_A2 | Up | 0.3171215593 |
| PubMed_21979375_A1 | Up | 0.3348721050 |
| PubMed_21979375_A2 | Down | -0.2726025582 |
| GSE35957 | Down | -0.0213745713 |
| GSE36640 | Up | 0.2693253149 |
| GSE54402 | Up | 0.1171265432 |
| GSE9593 | Up | 0.1459787007 |
| GSE43922 | Down | -0.0742771526 |
| GSE24585 | Up | 0.1183632193 |
| GSE37065 | Down | -0.2211185588 |
| GSE28863_A1 | Up | 0.0728592850 |
| GSE28863_A2 | Up | 0.0665817529 |
| GSE28863_A3 | Down | -0.0930968114 |
| GSE28863_A4 | Down | -0.2600190262 |
| GSE48662 | Down | -0.3782993862 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30d-5p | MIMAT0000245 | MIRT003274 | Western blot//Reporter assay;Other | Functional MTI | 20054866 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005181 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022392 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023620 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-935 | MIMAT0004978 | MIRT036699 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036851 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT043588 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044144 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-30d-5p | MIMAT0000245 | 1 | hsa-miR-30d | {Western blot} | {overexpression} | 20054866 | |
| hsa-miR-30d-5p | MIMAT0000245 | 2 | hsa-miR-30d | {Western blot} | {overexpression} | 20054866 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
