HCSGD entry for GLUL

1. General information

Official gene symbolGLUL
Entrez ID2752
Gene full nameglutamate-ammonia ligase
Other gene symbolsGLNS GS PIG43 PIG59
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001504Neurotransmitter uptakeTASbiological_process
GO:0004351Glutamate decarboxylase activityIEAmolecular_function
GO:0004356Glutamate-ammonia ligase activityEXPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006538Glutamate catabolic processTASbiological_process
GO:0006542Glutamine biosynthetic processTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0016595Glutamate bindingIEAmolecular_function
GO:0030145Manganese ion bindingIEAmolecular_function
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043204PerikaryonIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043679Axon terminusIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045503Dynein light chain bindingIEAmolecular_function
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97908824510.00631494620.99999024730.1617048591

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3852244030
GSE13712_SHEARDown-0.4767133509
GSE13712_STATICDown-0.4545222302
GSE19018Down-0.0590016141
GSE19899_A1Down-0.6960039894
GSE19899_A2Down-1.2198890418
PubMed_21979375_A1Down-0.0499580459
PubMed_21979375_A2Down-2.5178611427
GSE35957Up0.0654761853
GSE36640Down-0.8046632347
GSE54402Down-0.0606535507
GSE9593Down-0.0577363659
GSE43922Down-1.0850930250
GSE24585Down-0.0579556555
GSE37065Up0.0856443079
GSE28863_A1Up0.1223109939
GSE28863_A2Up0.3214596811
GSE28863_A3Down-0.3987386925
GSE28863_A4Down-0.0906113967
GSE48662Down-0.1942133351

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL131CHEMBL46128P15104
CHEMBL82546CHEMBL46128P15104
CHEMBL309243CHEMBL46128P15104
CHEMBL312041CHEMBL46128P15104
CHEMBL310570CHEMBL46128P15104
CHEMBL83110CHEMBL46128P15104
CHEMBL312399CHEMBL46128P15104
CHEMBL311662CHEMBL46128P15104
CHEMBL311322CHEMBL46128P15104
CHEMBL1160314CHEMBL46128P15104
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  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT004021Immunoblot//Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI19951903
hsa-miR-186-5pMIMAT0000456MIRT021141SequencingFunctional MTI (Weak)20371350
hsa-miR-183-5pMIMAT0000261MIRT025018SequencingFunctional MTI (Weak)20371350
hsa-miR-24-3pMIMAT0000080MIRT030540SequencingFunctional MTI (Weak)20371350
hsa-miR-320bMIMAT0005792MIRT036244CLASHFunctional MTI (Weak)23622248
hsa-miR-937-3pMIMAT0004980MIRT036638CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036966CLASHFunctional MTI (Weak)23622248
hsa-miR-877-5pMIMAT0004949MIRT037273CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038153CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038394CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-3pMIMAT0004602MIRT038640CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040016CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041957CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044856CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045330CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045626CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048155CLASHFunctional MTI (Weak)23622248
hsa-let-7f-5pMIMAT0000067MIRT051362CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051664CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052399CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22465014In addition, clusterin was found to prevent the inactivation of glutamine synthetase (GS) by metal-catalyzed oxidation (MCO) in vitro, and this protection was only supported by thiol-reducing equivalents, such as, DTT or GSH, and not by ascorbate (a non-thiol MCO system)
22363787Moreover, astroglial glutamate transporters and glutamine synthetase decreased in the Bmi-1 null hippocampus, which might contribute to the sporadic epileptic-like seizures in these mice
2870196Glial cell cultures derived from newborn and aged (18-month-old) mouse cerebral hemispheres and maintained up to cell passage 11 were characterized immunocytochemically by using glial fibrillary acidic protein (GFA), and biochemically by using glutamine synthetase (GS), for astrocytes, and 2',3' cyclic nucleotide 3' phosphohydrolase (CNP) for oligodendrocytes
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