HCSGD entry for GLRA1

1. General information

Official gene symbolGLRA1
Entrez ID2741
Gene full nameglycine receptor, alpha 1
Other gene symbolsHKPX1 STHE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001508Action potentialIEAbiological_process
GO:0001964Startle responseIMPbiological_process
GO:0002087Regulation of respiratory gaseous exchange by neurological system processIEAbiological_process
GO:0005230Extracellular ligand-gated ion channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDA IEA IMP NAScellular_component
GO:0006811Ion transportIDAbiological_process
GO:0006821Chloride transportIDAbiological_process
GO:0006936Muscle contractionIMPbiological_process
GO:0007218Neuropeptide signaling pathwayIDAbiological_process
GO:0007340Acrosome reactionIEAbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneNAScellular_component
GO:0016594Glycine bindingIDA IEAmolecular_function
GO:0016934Extracellular-glycine-gated chloride channel activityIDA IGI IMPmolecular_function
GO:0022824Transmitter-gated ion channel activityIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030977Taurine bindingIDAmolecular_function
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034707Chloride channel complexIEAcellular_component
GO:0042391Regulation of membrane potentialIMPbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0045202SynapseIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0050884Neuromuscular process controlling postureIEAbiological_process
GO:0051970Negative regulation of transmission of nerve impulseIMPbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060012Synaptic transmission, glycinergicIEAbiological_process
GO:0060013Righting reflexIEAbiological_process
GO:0060080Regulation of inhibitory postsynaptic membrane potentialIEAbiological_process
GO:1902476Chloride transmembrane transportIDA IGI IMPbiological_process
GO:2000344Positive regulation of acrosome reactionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85638611370.72944365340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1289171343
GSE13712_SHEARDown-0.0925101351
GSE13712_STATICDown-0.0944677540
GSE19018Up0.0359727658
GSE19899_A1Up0.0934903868
GSE19899_A2Up0.1068482604
PubMed_21979375_A1Down-0.1303632686
PubMed_21979375_A2Up0.0042666450
GSE35957Down-0.0790622286
GSE36640Down-0.1065263994
GSE54402Up0.0904873081
GSE9593Down-0.0397109779
GSE43922Up0.0205389681
GSE24585Down-0.0718349587
GSE37065Up0.0793327799
GSE28863_A1Down-0.0941123115
GSE28863_A2Up0.0829100127
GSE28863_A3Up0.0235708199
GSE28863_A4Down-0.0024730049
GSE48662Down-0.0722459927

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlycineDB00145 NUTR00028
IsofluraneDB00753 APRD00212
MethoxyfluraneDB01028 APRD00744
DesfluraneDB01189 APRD00907
SevofluraneDB01236 APRD00219
Ginkgo bilobaDB01381 -
D-SerineDB03929 EXPT01275
GW 468816DB05417 -
ThiocolchicosideDB11582 -
EnfluraneDB00228 APRD00234

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.