HCSGD entry for GLO1
1. General information
| Official gene symbol | GLO1 |
|---|---|
| Entrez ID | 2739 |
| Gene full name | glyoxalase I |
| Other gene symbols | GLOD1 GLYI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004462 | Lactoylglutathione lyase activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0006749 | Glutathione metabolic process | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0009438 | Methylglyoxal metabolic process | IEA | biological_process |
| GO:0030316 | Osteoclast differentiation | ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA IMP TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9857843585 | 0.0189316971 | 0.9999902473 | 0.2699356446 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2836614436 |
| GSE13712_SHEAR | Down | -0.3947209033 |
| GSE13712_STATIC | Down | -0.2590022127 |
| GSE19018 | Up | 0.3969084219 |
| GSE19899_A1 | Down | -0.5645018493 |
| GSE19899_A2 | Down | -0.4536571275 |
| PubMed_21979375_A1 | Down | -0.5405167069 |
| PubMed_21979375_A2 | Down | -0.4784484067 |
| GSE35957 | Down | -0.2812957388 |
| GSE36640 | Down | -0.4813147181 |
| GSE54402 | Down | -0.0832747297 |
| GSE9593 | Down | -0.0925817653 |
| GSE43922 | Down | -0.2870018666 |
| GSE24585 | Down | -0.2034239143 |
| GSE37065 | Down | -0.1488895906 |
| GSE28863_A1 | Up | 0.1619061958 |
| GSE28863_A2 | Up | 0.4238129684 |
| GSE28863_A3 | Down | -0.2908723145 |
| GSE28863_A4 | Down | -0.2424626134 |
| GSE48662 | Down | -0.4098617104 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
| Indomethacin | DB00328 | APRD00109 |
| S-P-Nitrobenzyloxycarbonylglutathione | DB03130 | EXPT01625 |
| S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione | DB03330 | EXPT01593 |
| Beta-Mercaptoethanol | DB03345 | EXPT02882 | DB03131 |
| S-Benzyl-Glutathione | DB03602 | EXPT01647 |
| S-Hexylglutathione | DB04132 | EXPT01664 |
| methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate | DB08179 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016416 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025781 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032365 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046725 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047098 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049258 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050980 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22188542 | MG-mediated damage is countered by glutathione-dependent metabolism by Glo1 (glyoxalase 1) |
| 22188542 | It is not known, however, whether Glo1 has stress-responsive up-regulation to counter periods of high MG concentration or dicarbonyl stress |
| 22188542 | We identified a functional ARE (antioxidant-response element) in the 5'-untranslated region of exon 1 of the mammalian Glo1 gene |
| 22188542 | We conclude that dicarbonyl stress is countered by up-regulation of Glo1 in the Nrf2 stress-responsive system, protecting protein and DNA from increased damage and preserving cell function |
| 22001178 | Glyoxalase I retards renal senescence |
| 22001178 | We hypothesized that carbonyl stress causes senescence and investigated the possible role of glyoxalase I (GLO1), which detoxifies precursors of advanced glycation end products in the aging process of the kidney |
| 22001178 | We used GLO1 overexpression or knockdown in primary renal proximal tubular epithelial cells to investigate the effect of GLO1 on cellular senescence |
| 22001178 | Furthermore, we confirmed the association of decreased GLO1 enzymatic activity and age-dependent deterioration of renal function in aged humans with GLO1 mutation |
| 22001178 | These findings indicate that GLO1 ameliorates carbonyl stress to retard renal senescence |
| 1756776 | Eight enzyme loci (G6PD, PGM1, PGM3, PepA, PGD, ADA, GLO1, and ME), proved to be informative in establishing unique allozyme genetic signatures for all of the cell strains established from the same species and from the same organ |
| 3994738 | It was metabolized by glyoxalase I with reduced glutathione to S-glyceroyl glutathione which was subsequently enzymatically hydrolyzed to reduced glutathione and glycerate by glyoxalase II |
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