HCSGD entry for MCAT
1. General information
| Official gene symbol | MCAT |
|---|---|
| Entrez ID | 27349 |
| Gene full name | malonyl CoA:ACP acyltransferase (mitochondrial) |
| Other gene symbols | FASN2C MCT MT NET62 fabD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004314 | [acyl-carrier-protein] S-malonyltransferase activity | IDA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006633 | Fatty acid biosynthetic process | IDA IEA | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0016740 | Transferase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0419154819 | 0.6848057179 | 0.4575932808 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4917136878 |
| GSE13712_SHEAR | Down | -0.4578931364 |
| GSE13712_STATIC | Up | 0.1665904730 |
| GSE19018 | Down | -0.0439378145 |
| GSE19899_A1 | Up | 0.3025723375 |
| GSE19899_A2 | Up | 1.4557999903 |
| PubMed_21979375_A1 | Up | 1.1514053496 |
| PubMed_21979375_A2 | Up | 0.9059999412 |
| GSE35957 | Down | -0.4714897736 |
| GSE36640 | Down | -0.0738488286 |
| GSE54402 | Up | 0.2966852301 |
| GSE9593 | Down | -0.1496255039 |
| GSE43922 | Up | 0.5313462154 |
| GSE24585 | Down | -0.1336070858 |
| GSE37065 | Down | -0.1710780084 |
| GSE28863_A1 | Up | 0.0053776830 |
| GSE28863_A2 | Down | -0.2187084619 |
| GSE28863_A3 | Down | -0.4886539191 |
| GSE28863_A4 | Up | 0.0564451556 |
| GSE48662 | Up | 0.2897080080 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL | DB07344 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027789 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032453 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23383735 | In this study, we characterized behavioral and cognitive performance of 5- to 6-month-old mice over-expressing mitochondrial catalase (MCAT) |
| 23383735 | MCAT mice showed enhancements in hippocampus-dependent spatial learning and memory in the water maze and contextual fear conditioning, and reduced measures of anxiety in the elevated zero maze |
| 23383735 | Catalase activity was elevated in MCAT mice in all brain regions examined |
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