HCSGD entry for GCLM
1. General information
| Official gene symbol | GCLM |
|---|---|
| Entrez ID | 2730 |
| Gene full name | glutamate-cysteine ligase, modifier subunit |
| Other gene symbols | GLCLR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0004357 | Glutamate-cysteine ligase activity | IDA IMP | molecular_function |
| GO:0005829 | Cytosol | NAS TAS | cellular_component |
| GO:0006534 | Cysteine metabolic process | IEA | biological_process |
| GO:0006536 | Glutamate metabolic process | IDA | biological_process |
| GO:0006750 | Glutathione biosynthetic process | IDA IEA IMP TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IDA | biological_process |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0017109 | Glutamate-cysteine ligase complex | IEA | cellular_component |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0035226 | Glutamate-cysteine ligase catalytic subunit binding | IPI | molecular_function |
| GO:0035229 | Positive regulation of glutamate-cysteine ligase activity | IEA | biological_process |
| GO:0042493 | Response to drug | IDA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0050880 | Regulation of blood vessel size | IMP | biological_process |
| GO:0051409 | Response to nitrosative stress | IEA | biological_process |
| GO:0051900 | Regulation of mitochondrial depolarization | IEA | biological_process |
| GO:1901687 | Glutathione derivative biosynthetic process | TAS | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0422578739 | 0.1072336537 | 0.4592359620 | 0.6265254162 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6062183357 |
| GSE13712_SHEAR | Up | 0.7615428027 |
| GSE13712_STATIC | Up | 0.6687798832 |
| GSE19018 | Down | -0.1254654843 |
| GSE19899_A1 | Down | -0.8494642937 |
| GSE19899_A2 | Down | -0.1303260682 |
| PubMed_21979375_A1 | Down | -0.3507670059 |
| PubMed_21979375_A2 | Down | -0.3771032879 |
| GSE35957 | Up | 0.0229636717 |
| GSE36640 | Up | 0.5875875448 |
| GSE54402 | Up | 0.8185221379 |
| GSE9593 | Up | 0.8445390631 |
| GSE43922 | Up | 0.0231493208 |
| GSE24585 | Down | -1.0642028793 |
| GSE37065 | Up | 0.0216885254 |
| GSE28863_A1 | Up | 0.2482368585 |
| GSE28863_A2 | Up | 0.3932079564 |
| GSE28863_A3 | Down | -0.7093645137 |
| GSE28863_A4 | Down | -0.0962871526 |
| GSE48662 | Up | 0.1391166966 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT050382 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051314 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19427898 | Although it is recognized that GCLM increases the rate of GSH synthesis, its physiological role is unclear |
| 19427898 | Herein, we show that loss of Gclm leads to premature senescence of primary murine fibroblasts as characterized by: (a) diminished growth rate, (b) cell morphology consistent with senescence, (c) increases in senescence-associated beta-galactosidase activity, and (d) cell cycle arrest at the G(1)/S and G(2)/M boundaries |
| 19427898 | These results suggest that the control of GCLM, which in turn controls aspects of the cellular redox environment via GSH, is important in determining the replicative capacity of the cell |
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