HCSGD entry for SMPDL3B
1. General information
| Official gene symbol | SMPDL3B |
|---|---|
| Entrez ID | 27293 |
| Gene full name | sphingomyelin phosphodiesterase, acid-like 3B |
| Other gene symbols | ASML3B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004767 | Sphingomyelin phosphodiesterase activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006685 | Sphingomyelin catabolic process | IEA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0016798 | Hydrolase activity, acting on glycosyl bonds | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6225381672 | 0.9099052012 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0071387538 |
| GSE13712_SHEAR | Down | -0.0071659242 |
| GSE13712_STATIC | Up | 0.0144541111 |
| GSE19018 | Up | 0.0324563614 |
| GSE19899_A1 | Up | 0.0232010865 |
| GSE19899_A2 | Up | 0.2400532273 |
| PubMed_21979375_A1 | Up | 0.0457383210 |
| PubMed_21979375_A2 | Down | -0.1130657434 |
| GSE35957 | Up | 0.0553874015 |
| GSE36640 | Down | -0.0136287014 |
| GSE54402 | Down | -0.0747282494 |
| GSE9593 | Up | 0.0415604608 |
| GSE43922 | Up | 0.0270754691 |
| GSE24585 | Up | 0.2172192911 |
| GSE37065 | Down | -0.1104091554 |
| GSE28863_A1 | Up | 0.0193663497 |
| GSE28863_A2 | Up | 0.0623983161 |
| GSE28863_A3 | Up | 0.2029562822 |
| GSE28863_A4 | Up | 0.1016091598 |
| GSE48662 | Up | 0.1700430282 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | MIRT052379 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
