HCSGD entry for TNFRSF21
1. General information
| Official gene symbol | TNFRSF21 |
|---|---|
| Entrez ID | 27242 |
| Gene full name | tumor necrosis factor receptor superfamily, member 21 |
| Other gene symbols | BM-018 CD358 DR6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051402 | Neuron apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0023913643 | 0.1279499031 | 0.1313320833 | 0.6892692182 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.3317477672 |
| GSE13712_SHEAR | Up | 1.0137043899 |
| GSE13712_STATIC | Up | 0.2752193537 |
| GSE19018 | Down | -1.3925485288 |
| GSE19899_A1 | Down | -0.3041089413 |
| GSE19899_A2 | Down | -0.5629178488 |
| PubMed_21979375_A1 | Up | 0.7812231195 |
| PubMed_21979375_A2 | Up | 2.2561785147 |
| GSE35957 | Up | 3.0380431037 |
| GSE36640 | Up | 1.4131219592 |
| GSE54402 | Down | -0.7909021953 |
| GSE9593 | Up | 0.3774095888 |
| GSE43922 | Up | 0.0103241424 |
| GSE24585 | Down | -0.8719567450 |
| GSE37065 | Up | 0.3490050189 |
| GSE28863_A1 | Up | 0.6085441978 |
| GSE28863_A2 | Up | 0.2264488356 |
| GSE28863_A3 | Up | 0.6455023937 |
| GSE28863_A4 | Down | -0.0631989704 |
| GSE48662 | Up | 0.0514474215 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002620 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002620 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016429 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020190 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027534 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028037 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24750067 | We also observed an abnormal expression of death receptor-6 and beta-amyloid precursor protein (APP) |
| 24750067 | Expression of APP, DR6, pTau (in GG and DNT) and caspase-3 (in GG) positively correlated with duration of epilepsy |
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